A Case of Neonatal Myeloid Sarcoma.

Here we describe a cutaneous neonatal myeloid sarcoma (MS) case with a subsequent diagnosis of acute myeloid leukemia (AML) seven days later. Cytogenetic studies were unusual demonstrating a triple copy of KAT6A abnormality and complex 8;14;22 translocation involving the 8p11.2 region.

Draize human repeat insult patch test (HRIPT): Seven decades of pitfalls and progress.

Allergic contact dermatitis, a Type IV delayed hypersensitivity reaction, can result in dermatologic signs/symptoms for patients/workers. The likelihood of this phenomenon has been estimated/predicted for numerous chemicals/drugs by animal model and human patch testing protocols developed over the last century. Karl Landsteiner initiated testing with guinea pig studies; further studies based on his initial concept were in continual development.

Incorporation of Women's Health Maintenance Screening in the USD Coyote Clinic.

Introduction: The Coyote Clinic is a student-run clinic that provides free services to Sioux Falls residents without insurance. It has not historically provided routine women's health screenings. The project addressed this lack of preventative care.

Skin Cancer Prevention and Screening Behaviors among Agricultural Workers: A Survey of the Attendees of the Sioux Falls Farm Show.

Introduction: Agricultural workers are at a higher risk for skin cancer due to excessive amounts of sun exposure, poor sun safety practices, and limited access to healthcare. This study aimed to assess skin cancer history, sun protection practices, and skin cancer surveillance measures among Midwestern agricultural workers.

Methods: Individuals that attended the 2020 Sioux Falls Farm Show were asked to complete a 12-question survey on sun exposure, sun protective practices, and skin cancer surveillance.

Percutaneous absorption of chemicals from fabric (textile).

Percutaneous penetration of chemicals from clothing can result in both acute and chronic toxicities. Although personal protective equipment composed of nonwoven material can provide thorough protection, it is often uncomfortable under normal occupational conditions. Certain everyday textiles are often utilized as protective clothing due to their cost, comfort, and convenience.

Effects of anatomical location on percutaneous penetration in man.

Purpose: Percutaneous penetration in man is affected by several factors: chemical properties, skin anatomy variables, and environmental conditions can all modify the quantity of chemical that penetrates through the skin barrier. The amount of chemical or drug that penetrates the cutaneous barrier must be considered due to the local and systemic absorption that may occur. Regional variation in percutaneous absorption is an additional factor to recognize when analysing chemical percutaneous penetration.

In vivo modeling of docosahexaenoic acid and eicosapentaenoic acid-mediated inhibition of both platelet function and accumulation in arterial thrombi.

Omega-3 polyunsaturated fatty acids (n-3 PUFAs) are associated with a variety of cellular alterations that mitigate cardiovascular disease. However, pinpointing the positive therapeutic effects is challenging due to inconsistent clinical trial results and overly simplistic in vitro studies. Here we aimed to develop realistic models of n-3 PUFA effects on platelet function so that preclinical results can better align with and predict clinical outcomes.