T2-signal intensity, SSTR expression, and somatostatin analogs efficacy predict response to pasireotide in acromegaly.

Objective: T2-signal intensity and somatostatin (SST) receptor expression are recognized predictors of therapy response in acromegaly. We investigated the relationship between these predictors and the hormonal and tumoral responses to long-acting pasireotide (PAS-LAR) therapy, which were also compared with responsiveness to first-generation somatostatin receptor ligands (SRLs).

Design: The PAPE study is a cohort study.

Diagnostic accuracy of MRI and ultrasound in chronic immune-mediated neuropathies.

Objective: To assess and compare the diagnostic performance of qualitative and (semi-)quantitative MRI and ultrasound for distinguishing chronic inflammatory demyelinating polyneuropathy (CIDP) and multifocal motor neuropathy (MMN) from segmental spinal muscular atrophy (sSMA).

Methods: Patients with CIDP (n = 13), MMN (n = 10), or sSMA (n = 12) and healthy volunteers (n = 30) were included. MRI of the brachial plexus, using short tau inversion recovery (STIR), nerve-specific T2-weighted (magnetic resonance neurography [MRN]), and diffusion tensor imaging (DTI) sequences, was evaluated.

Multiscale 3-D + T intracranial aneurysmal flow vortex detection.

Objective: Characteristics of vortices within intracranial aneurysmal flow patterns have been associated with increased risk of rupture. The classifications of these vortex characteristics are commonly based upon qualitative scores, and are, therefore, subjective to user interpretation. We present a quantitative method for automatic time-resolved characterization of 3-D flow patterns and vortex detection within aneurysms.

Wall shear stress estimated with phase contrast MRI in an in vitro and in vivo intracranial aneurysm.

Purpose: To evaluate wall shear stress (WSS) estimations in an in vitro and in vivo intracranial aneurysm, WSS was estimated from phase contrast magnetic resonance imaging (PC-MRI) and compared with computational fluid dynamics (CFD).

Materials And Methods: First, WSS was estimated using a high-resolution in vitro PC-MRI measurement under steady and pulsatile flow conditions and compared with CFD simulations. Second, WSS was estimated in steady PC-MRI data acquired at different spatial resolutions.

k-t BLAST and SENSE accelerated time-resolved three-dimensional phase contrast MRI in an intracranial aneurysm.

Objective: The objective of this study was to investigate the performance of k-t BLAST (Broad-use Linear Acquisition Speed-up Technique) accelerated time-resolved 3D PC-MRI compared to SENSE (SENSitivity Encoding) acceleration in an in vitro and in vivo intracranial aneurysm.

Materials And Methods: Non-accelerated, SENSE and k-t BLAST accelerated time-resolved 3D PC-MRI measurements were performed in vivo and in vitro. We analysed the consequences of various temporal resolutions in vitro.

Multiscale flow patterns within an intracranial aneurysm phantom.

Straightforward quantification of variations of flow patterns within aneurysms fails to accurately describe flow patterns of interest. We applied a multiscale decomposition of the flow in well-defined patterns to detect and quantify flow patterns in an aneurysm phantom that was studied with three different modalities: MRI, computational fluid dynamics, and particle image velocimetry. The method intuitively visualizes main patterns such as locally uniform flow, in- and outflow, and vortices.