Publications by authors named "Joost van Dullemen"
Brain Res Mol Brain Res
January 2004
Article Synopsis
- Researchers cloned two variants of the DCLK gene, named DCLK-short-A and DCLK-short-B, which encode different CaMK-like proteins with unique C-terminal ends.
- In situ hybridization revealed that both variants have distinct expression patterns in various brain regions, with DCLK-short-A being more prevalent in the subependymal zone, while DCLK-short-B shows stronger expression in areas like the cortex and hypothalamic nuclei.
- Both variants phosphorylate specific CaMK substrates, and the removal of their C-terminal ends significantly boosts kinase activity, suggesting these ends serve as auto-inhibitory domains that regulate different neuronal functions.
