Publications by authors named "Joost L Kluiver"
Article Synopsis
- Diagnosing post-transplant lymphoproliferative disorder (PTLD) is tough and often needs complicated tests, but checking cell-free DNA (cfDNA) in plasma is easier and might help identify PTLD quickly.
- In a study with 17 patients who had PTLD after organ transplants, many had the Epstein-Barr virus (EBV) in their tumors, and most were in advanced stages of the disease.
- The researchers found specific DNA changes in the cfDNA, with some common mutations linked to serious issues in the body, suggesting that cfDNA analysis could be a useful tool for screening and tracking PTLD.
Introduction: Non-small cell lung cancer (NSCLC) patients with Anaplastic Lymphoma Kinase (ALK) gene fusions respond well to ALK inhibitors but commonly develop on-target resistance mutations. The objective of this study is to collect clinical evidence for subsequent treatment with ALK inhibitors.
Patients And Methods: Local experience with on-target ALK resistance mutations and review of the literature identified 387 patients with ALK inhibitor resistance mutations.
There are several indications that classical Hodgkin lymphoma (cHL) and at least a proportion of cases of Primary Mediastinal B cell Lymphoma (PMBL) are derived from B cells at similar stages of differentiation and share common pathogenic mechanisms. The first indication was the existence of mediastinal grey zone lymphomas as identified in the 4th International Symposium on HL, with clinical, histological and immunohistochemical features intermediate between cHL and PMBL. Second, both tumor types resemble a cell that is developmentally situated in-between the germinal center reaction and a plasma cell.
View Article and Find Full Text PDF