Publications by authors named "Joon-Kyu Kim"
Background: Poly(lactic-co-glycolic acid) (PLGA) microspheres have been actively used in various pharmaceutical formulations because they can sustain active pharmaceutical ingredient release and are easy to administer into the body using a syringe. However, the acidic byproducts produced by the decomposition of PLGA cause inflammatory reactions in surrounding tissues, limiting biocompatibility. Magnesium hydroxide (MH), an alkaline ceramic, has attracted attention as a potential additive because it has an acid-neutralizing effect.
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- Histone deacetylases (HDACs), particularly HDAC2, play a critical role in regulating gene expression by removing acetyl groups from histone proteins, which affects chromatin structure; HDAC2 is notably elevated in the brains of Alzheimer's disease (AD) patients.
- Research shows that HDAC2 suppresses the expression of neuron-specific Endophilin-B1 (Endo-B1), with decreased levels of this protein linked to neuron death, mitochondrial dysfunction, and neurotoxicity under conditions associated with beta-amyloid exposure.
- Experiments in mice show that knocking out HDAC2 leads to improved neuronal survival and reduced brain injury in stroke models, suggesting that targeting HDAC2 could help counteract neuro
Clinical and radiographic outcomes of immediate and delayed placement of dental implants in molar and premolar regions.
Clin Implant Dent Relat Res
August 2017
Article Synopsis
- The study compared the outcomes of immediate versus delayed dental implant placements in the molar and premolar regions by analyzing clinical and radiographic data from 116 patients.
- Results showed no significant differences in survival rates, with delayed implants having a 97.8% survival rate over 9 years, and immediate implants showing 100% survival over 8 years.
- However, cervical bone loss (CBL) was found to be significantly less in the delayed placement group on the distal side, indicating potential benefits of delayed implant surgery.