Publications by authors named "Joon-Joon Khoo"
Literature review demonstrated a surprising lack of publications on digital e-learning pathology resources for senior medical undergraduates and interns. An interactive Digital Pathology Repository (iDPR) integrating two- and three-dimensional (2D, 3D) high-resolution anatomical pathology images with correlated digital histopathology was developed. The novel iDPR was rigorously evaluated using mixed methods to assess pathology knowledge gains (pre- and post-tests), quality impact analysis (questionnaire), user feedback (focus group discussions) and user visual behaviour (eye gaze tracking analysis of 2D/ 3D images).
View Article and Find Full Text PDFDespite the lack of its toxicity evaluation, traditional herbal products are being widely used for various health indications. Geraniin, an ellagitannin, is a bioactive compound found in many traditional herbal medicines. In spite its numerous health benefits ranging from anti-inflammatory, anti-hyperglycaemic, hepatoprotective, anti-cancer and anti-microbial, no toxicity data on geraniin is available.
View Article and Find Full Text PDFBackground: Dengue continues to be a major international public health concern. Despite that, there is no clinically approved antiviral for treatment of dengue virus (DENV) infections. In this study, geraniin extracted from the rind of Nephelium lappaceum was shown to inhibit the replication of DENV-2 in both in vitro and in vivo experiments.
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- The study introduces an automated system for quantifying interstitial fibrosis in renal biopsy images, aiming to address inconsistencies in visual evaluation by pathologists.
- This system uses color and structural analysis to accurately segment and measure the fibrosis, enhancing reliability across different pathologist assessments.
- Validation against a dataset prepared with expert input shows that the automated system's results align well with pathologists' evaluations, minimizing human error and variability in diagnosis.
Article Synopsis
- Examination of sentinel lymph node biopsies is critical for accurate nodal staging in breast cancer and impacts patient management.
- Increasing detail in the histopathological examination enhances metastatic tumor detection but may overload labs, necessitating balanced standard recommendations.
- In this study, while thin slicing and serial sectioning improved metastasis detection, the process may not be cost-effective, and false negatives could arise from technical issues or metastases skipping sentinel nodes.
Objectives: This study explored the risk factors and outcomes associated with perforation in children who underwent emergency appendicectomies.
Methods: A retrospective cross-sectional study was conducted on children <13 years old who underwent appendicectomies in a Malaysian hospital in 2007.
Results: One hundred thirty-four children underwent appendicectomies of which 118 were confirmed histologically.
Breast hamartoma is an uncommon poorly recognised benign breast neoplasm. Hamartoma displaying marked smooth muscle components known as myoid hamartoma of the breast is a much rarer entity. We present a case of myoid hamartoma of breast with chondroid differentiation in a 46-year-old woman.
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- An audit reviewed 1122 cholecystectomies over six years (2000-2005) to identify cases of primary gallbladder carcinoma, revealing nine instances of the cancer.
- Only two patients were clinically suspected of having cancer before surgery, while others were misdiagnosed with conditions like cholecystitis or gallstones.
- The study underscores the need for thorough evaluation during pathological examinations of gallbladders removed due to other issues, highlighting a significant incidence of gallbladder carcinoma in a Malaysian hospital.
Article Synopsis
- Rosai-Dorfman disease (RDD) is a rare benign condition characterized by an overgrowth of histiocytes affecting lymph nodes and, in rare cases, the skin.
- A case study is presented involving a 34-year-old woman with cutaneous RDD, which showed large histiocytes in a skin nodule, with notable features such as emperipolesis and a mixed cell presence.
- Diagnosis can be challenging, requiring histopathological examination and a keen awareness from healthcare professionals, especially when lymph node involvement is absent.
A clinical and immunohistochemical study of gastrointestinal stromal tumours.
Malays J Pathol
June 2005
Aim: To study the clinical features, histology and immunohistochemical properties of gastrointestinal stromal tumours (GISTs); and establish any parameters that can help prognosticate the malignant potential.
Methods: Twenty-six patients with GISTs who were seen in Sultanah Aminah Hospital Johor, Malaysia from 1999 to 2003 were selected for study. Patient, clinical characteristics and outcome based on surgical records were analysed.
Article Synopsis
- Extramammary Paget's disease (EMPD) is a rare skin disorder that typically presents as chronic lesions in areas like the vulva, scrotum, and groin, often resembling eczema but may indicate serious internal malignancies.
- Two elderly cases of EMPD were reported, one in the scrotal region and the other in the vulva, both showing resistance to initial topical treatments; skin biopsies confirmed the diagnosis.
- Effective management requires surgical excision and a thorough investigation for underlying cancers, but since recurrence rates are high, long-term follow-up is essential.
Scar endometriosis presenting as an acute abdomen: a case report.
Aust N Z J Obstet Gynaecol
April 2003