Publications by authors named "Joon-Hwan Ji"
Purpose: is a Gram-positive bacterium that most frequently acquires antibiotic resistance. As an opportunistic pathogen, it can cause conditions such as bacteremia, sepsis, and myocarditis. Due to the social need for a vaccine against methicillin-resistant (MRSA), many research groups have been designing and studying vaccines for decades.
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- An in-house enzyme-linked immunosorbent assay (ELISA) was developed and validated for measuring mouse humoral immunogenicity using a standard curve from an international reference serum.
- During validation, the study confirmed key aspects like precision, dilution linearity, and specificity while comparing two calculation methods (RFL and PLL) and found no significant differences between them.
- The final results achieved appropriate coating concentrations and strong signal to noise ratios, meeting necessary accuracy criteria, indicating that the ELISA is a reliable tool for immunogenicity testing in mice.
Safety assessments of recombinant DTaP vaccines developed in South Korea.
Clin Exp Vaccine Res
April 2024
Purpose: Pertussis bacteria have many pathogenic and virulent antigens and severe adverse reactions have occurred when using inactivated whole-cell pertussis vaccines. Therefore, inactivated acellular pertussis (aP) vaccines and genetically detoxified recombinant pertussis (rP) vaccines are being developed. The aim of this study was to assess the safety profile of a novel rP vaccine under development in comparison to commercial diphtheria-tetanus-acellular pertussis (DTaP) vaccines.
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