Publications by authors named "Joon Yuhl Soh"
Background: Coronary artery disease (CAD) is the leading cause of death worldwide. Recent meta-analyses of genome-wide association studies have identified over 175 loci associated with CAD. The majority of these loci are in noncoding regions and are predicted to regulate gene expression.
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- Coronary artery disease (CAD) is a leading cause of death globally, and recent studies have identified 163 genetic loci linked to CAD, though the exact mechanisms remain unclear.
- This research aimed to find genetic variants linked to key atherosclerosis-related traits in vascular smooth muscle cells (VSMCs), which are crucial in CAD development and can have both positive and negative effects.
- The study found significant variations in VSMC traits such as calcification and proliferation and identified four key genetic loci associated with these traits, including one that suggests lower VSMC activity could reduce CAD risk.
Sex differences in adipose tissue distribution and function are associated with sex differences in cardiometabolic disease. While many studies have revealed sex differences in adipocyte cell signaling and physiology, there is a relative dearth of information regarding sex differences in transcript abundance and regulation. We investigated sex differences in subcutaneous adipose tissue transcriptional regulation using omic-scale data from ∼3000 geographically and ethnically diverse human samples.
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