Serglycin controls megakaryocyte retention of platelet factor 4 and influences megakaryocyte fate in bone marrow.

Megakaryocytes (MKs) produce platelets, and like other hematopoietic progenitors they are involved in homeostatic aspects of their bone marrow niche. MKs release and endocytose various factors, such as platelet factor 4 (PF4/CXCL4). Here we show that the intra-α-granular proteoglycan, serglycin (SRGN) plays a key role in this process by retaining PF4 and perhaps other factors during MK maturation.

Bimetallic Gold-Silver Nanostructures Drive Low Overpotentials for Electrochemical Carbon Dioxide Reduction.

Alloy formation is an advanced approach to improve desired properties that the monoelements cannot achieve. Alloys are usually designed to tailor intrinsic natures or induce synergistic effects by combining materials with distinct properties. Indeed, unprecedented properties have emerged in many cases, superior to a simple sum of pure elements.

Observation of 3D Biexcitons in Pristine-Quality CH NH PbBr Single Crystals.

Halide perovskites (HPs) are fascinating materials whose optoelectronic properties are arguably excitonic. In the HP family, biexcitons are known to exist only in low dimensions where exciton-exciton binding is strongly enhanced by quantum and dielectric confinements. In this paper, however, it is shown that they indeed do exist in 3D bulk CH NH PbBr (MAPbBr ) single crystals if the pristine crystal quality is ensured for subtle binding of two excitons.

Surface overgrowth on gold nanoparticles modulating high-energy facets for efficient electrochemical CO reduction.

Electrochemical CO reduction reaction (eCORR) has been considered one of the potential technologies to store electricity from renewable energy sources into chemical energy. For this aim, designing catalysts with high surface activities is critical for effective eCORR. In this study, we introduced a surface overgrowth method on stable Au icosahedrons to generate Au nanostars with large bumps.

Tsg101 Is Necessary for the Establishment and Maintenance of Mouse Retinal Pigment Epithelial Cell Polarity.

The retinal pigment epithelium (RPE) forms a monolayer sheet separating the retina and choroid in vertebrate eyes. The polarized nature of RPE is maintained by distributing membrane proteins differentially along apico-basal axis. We found the distributions of these proteins differ in embryonic, post-natal, and mature mouse RPE, suggesting developmental regulation of protein trafficking.

Adult Ileocolic Intussusception Caused by Diffuse Large B Cell Lymphoma.

Intussusception is a medical condition, in which a proximal part of the intestine folds into the distal intestine. Adult intussusceptions are rare and account for approximately 5% of all cases of intussusceptions. The anatomical leading points include tumors, diverticulums, polyps, and strictures in 80-90% of adult intussusceptions, and 65% of colon intussusceptions and 30% of small bowel intussusceptions originate from malignant tumors.

Strategies for Designing Nanoparticles for Electro- and Photocatalytic CO Reduction.

Conversion of carbon dioxide (CO ) into value-added chemicals has attracted much attention because it can not only resolve global warming issues by reducing CO accumulation in the atmosphere, but also produce renewable hydrocarbon fuels that are important feedstocks for the chemical industry. Among the diverse approaches reported, CO reduction via electro- and photocatalytic methods is at the center of topics due to potential engineering of reaction performance through rational design of catalyst features. In this Minireview, we highlight recent strategies for designing nanoparticles to maximize the reaction efficiency and selectivity; from a materials viewpoint, these strategies can provide critical information to guide future research directions.

Resectability of Rectal Neuroendocrine Tumors Using Endoscopic Mucosal Resection with a Ligation Band Device and Endoscopic Submucosal Dissection.

Background: Rectal neuroendocrine tumors (NETs) < 10 mm in diameter, limited to the submucosa without local or distant metastasis, can be treated endoscopically. Endoscopic mucosal resection with a ligation band device (EMR-L) and endoscopic submucosal dissection (ESD) have been employed to resect rectal NETs. We evaluated and compared the clinical outcomes of EMR-L and ESD for endoscopic resection of rectal NETs G1 < 10 mm in diameter.

Risk factors for lymph node metastasis in duodenal neuroendocrine tumors: A retrospective, single-center study.

Duodenal neuroendocrine tumors (NETs) are rare, and risk factors associated with lymph node (LN) metastasis are still not well defined. The aim of this study was to investigate risk factors of LN metastasis in duodenal NETs based on the final histopathologic results and clinical follow-up data.This study included a total of 44 duodenal NETs in 38 patients who underwent endoscopic or surgical resection between January 2008 and December 2015.

Branched Copper Oxide Nanoparticles Induce Highly Selective Ethylene Production by Electrochemical Carbon Dioxide Reduction.

For long-term storage of renewable energy, the electrochemical carbon dioxide reduction reaction (CORR) offers a promising option for converting electricity to permanent forms of chemical energy. In this work, we present highly selective ethylene production dependent upon the catalyst morphology using copper oxide nanoparticles. The branched CuO nanoparticles were synthesized and then deposited on conductive carbon materials.

Neutropenic Enterocolitis due to Mucormycosis in a Patient with Myelodysplastic Syndrome.

Neutropenic enterocolitis is a fatal enterocolitis occurring in neutropenic patients with immunocompromised diseases including hematologic malignancies. Gastrointestinal (GI) mucormycosis in hematologic malignancies has been rarely reported. Especially, in myelodysplastic syndrome (MDS), GI mucormycosis has never been reported.

The Moderating Effects of Self-Esteem and Self-Efficacy on Responses to Graphic Health Warnings on Cigarette Packages: A Comparison of Smokers and Nonsmokers.

Do graphic pictorial health warnings (GPHWs) on cigarette packaging work better for some people than others? According to the Extended Parallel Process Model (EPPM), fear appeals should heighten positive change only if a person believes he or she is capable of change (i.e., self-efficacy).

σ-Complexation as a strategy for designing copper-based light emitters.

Strongly emissive cuprous complexes containing a stable σ-SiH-Cu motif were prepared. These complexes serve as a proof of principle that σ-complexation can be utilized as a design principle for engineering responsive light emitting materials. Their excited state lifetimes were found to be long (∼20 μs) with high quantum yields (φ = 0.

Antimicrobial activity of essential oil of Eucalyptus globulus against fish pathogenic bacteria.

The antibacterial activities of the essential oil of Eucalyptus globulus (EOEG) was determined against 7 fish pathogenic bacteria (Edwardsiella tarda, Streptococcus iniae, S. parauberis, Lactococcus garviae, Vibrio harveyi, V. ichthyoenteri and Photobacterium damselae) obtained from farmed olive flounder.

The Natural Course of Endobronchial Inflammatory Polyps as a Complication after Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration.

We presented a case of unusual endobronchial inflammatory polyps as a complication following endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) in a patient with tuberculous lymphadenitis. EBUS-TBNA of the right hilar lymph node was performed in a 29-year-old, previously healthy man. The patient was confirmed with tuberculous lymphadenitis and received antituberculosis medication over the course of 6 months.

Natural variation in Early flowering1 contributes to early flowering in japonica rice under long days.

Natural variation in heading-date genes enables rice, a short-day (SD) plant, to flower early under long-day (LD) conditions at high latitudes. Through analysis of heading-date quantitative trait loci (QTL) with F7 recombinant inbred lines from the cross of early heading 'H143' and late heading 'Milyang23 (M23)', we found a minor-effect Early Heading3 (EH3) QTL in the Hd16 region on chromosome 3. We found that Early flowering1 (EL1), encoding casein kinase I (CKI), is likely to be responsible for the EH3/Hd16 QTL, because a missense mutation occurred in the highly conserved serine/threonine kinase domain of EL1 in H143.

Novel 7-(dimethylamino)fluorene-based fluorescent probes and their binding to human serum albumin.

A novel solvatochromic fluorescent molecule, 9,9-dibutyl-7-(dimethylamino)-2-fluorenesulfonate 2 was synthesized from 2-nitrofluorene in moderate yield. The fluorescence spectra of 2 and 7-(dimethylamino)-2-fluorenesulfonate 1 shift to shorter wavelengths as the polarity of the medium decreases. Both 1 and 2 bind to hydrophobic sites of human serum albumin (HSA).

Solvent and pH effects on the fluorescence of 7-(dimethylamino)-2-fluorenesulfonate.

A novel water-soluble solvatochromic molecule, 7-(dimethylamino)-2-fluorenesulfonate (2,7-DAFS), was prepared by a three-step reaction from 2-nitrofluorene in good overall yield. The pH and solvent effects on the UV-VIS absorption and fluorescence spectra of 2,7-DAFS have been studied. Protonation of the dimethylamino group switches the absorption from intramolecular charge-transfer (ICT) to pi --> pi* transition.

Kinetics and mechanism of cyclodextrin inclusion complexation incorporating bidirectional inclusion and formation of orientational isomers.

The kinetics of cyclodextrin (CD) inclusion complexation has been usually analyzed in terms of a one-step reaction or a consecutive two-step reaction involving intracomplex structural transformation as a second step. These schemes presume the inclusion of guest molecules through only one side of the CD cavity and the formation of unidirectional CD complexes. However, there has been increasing experimental evidence for the inclusion of guests through both sides of the CD cavity and the formation of orientational isomers for noncentrosymmetric guest molecules.

Self-inclusion behavior and circular dichroism of aliphatic chain-linked beta-cyclodextrin-viologen compounds and their reduced forms depending on the side of modification.

[Reaction: see text]. The self-inclusion behavior and induced circular dichroism (ICD) characteristics of two beta-cyclodextrin (beta-CD) derivatives, in which a 1-methyl-4,4'-bipyridinium (viologen) group is connected by an octamethylene chain to either the primary (2(2+)) or secondary (3(2+)) side of beta-CD, and of their reduced forms, are investigated. 1H NMR studies showed that 2(2+) forms an intramolecular self-inclusion complex with K(in) = 3.

Isomeric [2]rotaxanes and unidirectional [2]pseudorotaxane composed of alpha-cyclodextrin and aliphatic chain-linked carbazole-viologen compounds.

[structure: see text] Capping the alpha-cyclodextrin (alpha-CD) complex of 1-(N-carbazole)-10-[4-(4-pyridinio)-1-pyridinio]decane with 3,5-dimethoxybenzyl bromide in DMF gives two isomeric [2]rotaxanes, 2a and 2b, while alpha-CD and 1-(N-carbazole)-10-[4-(1-methyl-4-pyridnino)-1-pyridinio]decane 3 in water form mostly a unidirectional [2]pseudorotaxane having the same alpha-CD orientation as 2b. Structures were elucidated from 1H NMR and circular dichroism spectra. The orientational specificity of alpha-CD in the 3/alpha-CD [2]pseudorotaxane is due to the slow dethreading rate of the 2b-type isomer.