Publications by authors named "Joon Soon Park"
Introduction: Serum level of high-mobility group box 1 protein is reportedly correlated with the severity of obstructive sleep apnea.
Objective: We tried to evaluate the possibility of using the serum high-mobility group box 1 protein level as a biologic marker in obstructive sleep apnea patients.
Methods: We generated a chronic intermittent hypoxia murine model that reflected human obstructive sleep apnea.
Article Synopsis
- The study investigates how high-mobility group box 1 (HMGB1) translocates in the body, particularly in allergic rhinitis (AR), and how this process is influenced by type 2 helper T cell (Th2) cytokines.
- Researchers found that in cases of AR, HMGB1 levels increased both in cells and outside of them, and inhibiting its movement led to reduced allergy markers, such as antigen-specific IgE.
- The study proposes a significant link between Th2 cytokines, reactive oxygen species (ROS), and the translocation of HMGB1, suggesting this pathway plays a key role in the development of allergic rhinitis.
Profiling of heat shock proteins 27 and 70 in adenoids of children.
Eur Arch Otorhinolaryngol
September 2019
Purpose: Heat shock protein (HSP)27 and 70 are molecular chaperones that may have immunomodulatory functions. We determined if and at what levels each are expressed in the adenoids of pediatric subjects. We also examined tissue distributions, associated clinical characteristics, and antibacterial effects.
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