Electrochemical Synthesis of Hollow Nanoparticles via Anodic Transformation of Metastable Core-Shell Precursors.

Recent advances in electrosynthesis of nanomaterials expanded structural and compositional variations accessible by the electrochemical method; however, reliably synthesizable morphological variety fall shy of that available by conventional solvothermal synthesis. In this communication, electrochemical preparation of surfactant-free hollow nanoparticles is demonstrated. By anodic conversion of core-shell precursors with metastable cores, hollowed nickel nanoparticles with uniform dimensions were synthesized and characterized.

Local Heating Induced Single-Crystalline Phase Control in Electrochemical Synthesis of Nanomaterials.

Development of synthetic strategies selectively yielding single crystals is desired owing to the facet-dependent chemical reactivities. Recent advances in electrochemical materials synthesis yielded nanomaterials that are surfactant-free, however, typically in polycrystalline forms. In this work, an electrochemical synthetic strategy selectively yielding single-crystalline nanoparticles by implementation of surface-selective heating of the working electrode is developed.

Laboratory evolution, transcriptomics, and modeling reveal mechanisms of paraquat tolerance.

Relationships between the genome, transcriptome, and metabolome underlie all evolved phenotypes. However, it has proved difficult to elucidate these relationships because of the high number of variables measured. A recently developed data analytic method for characterizing the transcriptome can simplify interpretation by grouping genes into independently modulated sets (iModulons).

The discrete single-entity electrochemistry of Pickering emulsions.

Single-entity analysis is an important research topic in electrochemistry. To date, electrode collisions and subsequent electrode-particle interactions have been studied for many types of nano-objects, including metals, polymers, and micelles. Here we extend this nano-object electrochemistry analysis to Pickering emulsions for the first time.

Organotropic Targeting of Biomimetic Nanoparticles to Treat Lung Disease.

Active targeting strategies aimed at improving drug homing while reducing systemic toxicity are widely being pursued in the growing field of nanomedicine. While they can be effective, these approaches often require the identification of cell-specific targets and in-depth knowledge of receptor binding interactions. More recently, there has been significant interest in biomimetic nanoformulations capable of replicating the properties of naturally occurring systems.

Electrochemical synthesis of core-shell nanoparticles by seed-mediated selective deposition.

Conventional solvothermal synthesis of core-shell nanoparticles results in them being covered with surfactant molecules for size control and stabilization, undermining their practicality as electrocatalysts. Here, we report an electrochemical method for the synthesis of core-shell nanoparticles directly on electrodes, free of surfactants. By implementation of selective electrodeposition on gold cores, 1-row transition metal shells were constructed with facile and precise thickness control.

Virus-Mimicking Cell Membrane-Coated Nanoparticles for Cytosolic Delivery of mRNA.

Effective endosomal escape after cellular uptake represents a major challenge in the field of nanodelivery, as the majority of drug payloads must localize to subcellular compartments other than the endosomes in order to exert activity. In nature, viruses can readily deliver their genetic material to the cytosol of host cells by triggering membrane fusion after endocytosis. For the influenza A virus, the hemagglutinin (HA) protein found on its surface fuses the viral envelope with the surrounding membrane at endosomal pH values.

Bacteria-Inspired Nanomedicine.

The natural world has provided a host of materials and inspiration for the field of nanomedicine. By taking design cues from naturally occurring systems, the nanoengineering of advanced biomimetic platforms has significantly accelerated over the past decade. In particular, the biomimicry of bacteria, with their motility, taxis, immunomodulation, and overall dynamic host interactions, has elicited substantial interest and opened up exciting avenues of research.

Relationship between Competency to Consent to Treatment and Psychological Well-Being: Mediating Effect of Empowerment and Emotion.

This study was conducted to evaluate the competency to consent to the treatment of psychiatric outpatients and to confirm the role of empowerment and emotional variables in the relationship between competency to consent to treatment and psychological well-being. The study participants consisted of 191 psychiatric outpatients who voluntarily consented to the study among psychiatric outpatients. As a result of competency to consent to treatment evaluation, the score of the psychiatric outpatient's consent to treatment was higher than the cut-off point for both the overall and sub-factors, confirming that they were overall good.

Genetically engineered cell membrane-coated nanoparticles for targeted delivery of dexamethasone to inflamed lungs.

As numerous diseases are associated with increased local inflammation, directing drugs to the inflamed sites can be a powerful therapeutic strategy. One of the common characteristics of inflamed endothelial cells is the up-regulation of vascular cell adhesion molecule-1 (VCAM-1). Here, the specific affinity between very late antigen-4 (VLA-4) and VCAM-1 is exploited to produce a biomimetic nanoparticle formulation capable of targeting inflammation.

Biomimetic nanoparticle technology for cardiovascular disease detection and treatment.

Cardiovascular disease (CVD), which encompasses a number of conditions that can affect the heart and blood vessels, presents a major challenge for modern-day healthcare. Nearly one in three people has some form of CVD, with many suffering from multiple or intertwined conditions that can ultimately lead to traumatic events such as a heart attack or stroke. While the knowledge obtained in the past century regarding the cardiovascular system has paved the way for the development of life-prolonging drugs and treatment modalities, CVD remains one of the leading causes of death in developed countries.

Nanoparticle Delivery of Immunostimulatory Agents for Cancer Immunotherapy.

Immunostimulatory agents, including adjuvants, cytokines, and monoclonal antibodies, hold great potential for the treatment of cancer. However, their direct administration often results in suboptimal pharmacokinetics, vulnerability to biodegradation, and compromised targeting. More recently, encapsulation into biocompatible nanoparticulate carriers has become an emerging strategy for improving the delivery of these immunotherapeutic agents.

Stoichiometry-Controlled Synthesis of Nanoparticulate Mixed-Metal Oxyhydroxide Oxygen Evolving Catalysts by Electrochemistry in Aqueous Nanodroplets.

Mixed-metal oxyhydroxides-especially those of Ni and Fe-are one of the most active classes of materials known for catalyzing the oxygen evolution reaction (OER). Here, nanoparticulate mixed metal oxyhydroxides (of Ni, Fe, and Co) were prepared on an electrode surface by electrochemical reaction of a precursor solution encapsulated in aqueous nanodroplets (AnDs), with each of the droplets containing 10 s of attoliters of fluid. Electrode reactions and synthesis can be monitored in situ by electrochemistry as single AnD stochastically lands and interacts with the working electrode.

Cellular responses to reactive oxygen species are predicted from molecular mechanisms.

Catalysis using iron-sulfur clusters and transition metals can be traced back to the last universal common ancestor. The damage to metalloproteins caused by reactive oxygen species (ROS) can prevent cell growth and survival when unmanaged, thus eliciting an essential stress response that is universal and fundamental in biology. Here we develop a computable multiscale description of the ROS stress response in , called OxidizeME.

Identification of (R)-selective ω-aminotransferases by exploring evolutionary sequence space.

Several (R)-selective ω-aminotransferases (R-ωATs) have been reported. The existence of additional R-ωATs having different sequence characteristics from previous ones is highly expected. In addition, it is generally accepted that R-ωATs are variants of aminotransferase group III.

Effects of using mobile device-based academic electronic medical records for clinical practicum by undergraduate nursing students: A quasi-experimental study.

Introduction: The academic electronic medical record (AEMR) system is applied with the expectation that nursing students will be able to attain competence in healthcare decision-making and nursing informatics competencies. However, there is insufficient evidence regarding the advantage of applying mobile devices to clinical practicum.

Objectives: This study aimed to examine the effect of an experiment that introduced a mobile AEMR application for undergraduate nursing students in their practicum.

Microtensile bond strength and micromorphologic analysis of surface-treated resin nanoceramics.

Purpose: The aim of this study was to evaluate the influence of different surface treatment methods on the microtensile bond strength of resin cement to resin nanoceramic (RNC).

Materials And Methods: RNC onlays (Lava Ultimate) (n=30) were treated using air abrasion with and without a universal adhesive, or HF etching followed by a universal adhesive with and without a silane coupling agent, or tribological silica coating with and without a universal adhesive, and divided into 6 groups. Onlays were luted with resin cement to dentin surfaces.

Nursing Students' Satisfaction with Mobile Academic Electronic Medical Records for Undergraduate Clinical Practicum.

The purpose of study was to evaluate satisfaction with and usability of mobile academic electronic medical records (AEMR) for undergraduate nursing students' clinical practicum. After an AEMR application on mobile devices was applied to the experimental group while a PC-based EMR system was used for the control group as usual in the fall semester, 2014. Two items of practicum satisfaction such as preparation of lab test and understanding of the results, and nursing intervention and documentation were significantly higher in the experiment group.

Clinical and Radiologic Outcomes of Partial Lateral Patellar Facetectomy in Total Knee Arthroplasty.

Recently, some authors have performed partial lateral patellar facetectomy in total knee arthroplasty (TKA) and reported good results. However, research on partial lateral patellar facetectomy in TKA is still lacking. The aim of this study was to evaluate the clinical and radiologic results of partial lateral patellar facetectomies in patellar non-resurfacing and resurfacing TKAs.

Assessment of the Need to Integrate Academic Electronic Medical Records Into the Undergraduate Clinical Practicum: A Focus Group Interview.

As healthcare systems demand that nurses be competent in using electronic medical records for patient care, the integration of electronic medical records into nursing curricula has become necessary. The purpose of this study was to explore how students, new nurses, clinical instructors, and faculty perceive the integration of academic electronic medical records into the undergraduate clinical practicum. From January to February 2014, four focus group interviews with 18 participants were conducted based on purposive sampling.

Usability of Academic Electronic Medical Record Application for Nursing Students' Clinical Practicum.

Objectives: Nursing curricula for undergraduate nursing students need to reflect the information technology used in current nursing practice. A smart-device Academic Electronic Medical Record (AEMR) application can help nursing students access and document records for the clinical practicum. We conducted a pilot study to evaluate the usability of an AEMR application before applying it to the clinical nursing practicum.

Enhancement of X-ray detection by single-walled carbon nanotube enriched flexible polymer composite.

Unlabelled: Although organic-based direct conversion X-ray detectors have been developed, their photocurrent generation efficiency has been limited by recombination of excitons due to the intrinsically poor electrical properties of organic materials. In this report, we fabricated a polymer-based flexible X-ray detector and enhanced the X-ray detection sensitivity using a single-walled carbon nanotube (SWNT) enriched polymer composite. When this SWNT enriched polymer composite was used as the active layer of an X-ray detector, it efficiently separated charges at the interface between the SWNTs and polymer, preventing recombination of X-ray-induced excitons.

Clinical analysis of risk factors contributing to recurrence of pterygium after excision and graft surgery.

Aim: To find the risk factors related to the reproliferation of the pterygial tissue after excision and graft surgery.

Methods: Charts of 130 eyes of 130 patients who had pterygial excision from March 2006 to April 2011 were reviewed. Preoperative pterygium morphology, surgical methods, and adjunctive treatments were statistically analyzed for their relationship with recurrence.

A spot-matching method using cumulative frequency matrix in 2D gel images.

A new method for spot matching in two-dimensional gel electrophoresis images using a cumulative frequency matrix is proposed. The method improves on the weak points of the previous method called 'spot matching by topological patterns of neighbour spots'. It accumulates the frequencies of neighbour spot pairs produced through the entire matching process and determines spot pairs one by one in order of higher frequency.

Protein engineering of α2,3/2,6-sialyltransferase to improve the yield and productivity of in vitro sialyllactose synthesis.

In the large-quantity production of α2,3- and α2,6-sialyllactose (Neu5Ac(α2,3)Galβ1,4Glc (3'-SL) and Neu5Ac(α2,6)Galβ1,4Glc (6'-SL)) using sialyltransferases (STs), there are major hurdles to overcome for further improvement in yield and productivity of the enzyme reactions. Specifically, Pasteurella multocida α2,3-sialyltransferase (α2,3PST) forms a by-product to a certain extent, owing to its multifunctional activity at pH below 7.0, and Photobacterium damselae α2,6-sialyltransferase (α2,6PdST) shows relatively low ST activity.