Publications by authors named "Joo-Hun Park"
Connective tissue disease (CTD) comprising a various range of autoimmune disorders is often accompanied by lung involvement, which can lead to life-threatening complications. The main types of CTDs that can present as interstitial lung disease (ILD) include rheumatoid arthritis, systemic sclerosis, Sjögren's syndrome, mixed connective tissue disease, idiopathic inflammatory myopathies, and systemic lupus erythematosus. CTD-ILD poses a significant challenge in clinical diagnosis and management due to its heterogeneous nature and variable prognosis.
View Article and Find Full Text PDFIntroduction: Ca2+ signaling in fibroblasts would be one of the important mediators of lung fibrosis. This study investigated the relationship between calcium channel blocker usage and the risk of developing interstitial lung disease and idiopathic pulmonary fibrosis.
Material And Methods: This cohort study used data from the Korean National Health Screening Cohort spanned from January 1, 2004, to December 31, 2015.
Article Synopsis
- This study investigates pulmonary fibrosis-like changes in critically ill patients with SARS-CoV-2 pneumonia during two different variant periods: delta and pre-delta.
- Clinical data and chest CT images were analyzed from a total of 184 patients across two time periods, revealing that those infected during the delta variant period displayed more severe fibrosis-like changes.
- The findings indicate that patients during the delta period had a higher frequency of significant fibrotic changes compared to the pre-delta group, suggesting the delta variant may be associated with worse pulmonary outcomes.
Clinical Characteristics of Chronic Obstructive Pulmonary Disease according to Smoking Status.
Tuberc Respir Dis (Seoul)
January 2025
Article Synopsis
- - COPD (Chronic Obstructive Pulmonary Disease) can result from factors like infections, asthma, air pollution, and genetics, with smoking being the main risk factor.
- - Non-smokers with COPD show different characteristics, such as a normal rate of FEV1 decline, fewer comorbidities, milder airflow issues, and unique radiological features, but still face significant acute exacerbations.
- - COPD increases the risk of lung cancer regardless of smoking history, and managing other related health problems is crucial for effective treatment of COPD.
Article Synopsis
- - The study evaluated the safety and effectiveness of Fybro, a generic antifibrotic medication for idiopathic pulmonary fibrosis (IPF), with a focus on its real-world performance over 6-12 months.
- - Out of 359 patients enrolled, a large majority (71.9%) experienced adverse events, with decreased appetite being the most common issue; however, lung function decline rates did not vary significantly across different dosages of Fybro.
- - The findings suggest that using higher-dose Fybro tablets can enhance patient adherence to medication regimens, proposing that fewer pills daily may lead to better treatment compliance.
Characteristics of chronic obstructive pulmonary disease (COPD) patients with superoptimal peak inspiratory flow rates (PIFR) has not been thoroughly investigated. This study aimed to compare the characteristics between COPD patients with superoptimal PIFR and those with optimal and sub-optimal PIFR. PIFR was measured using In-Check DIAL G16 and categorized into sub-optimal (PIFR lower than that required by the patient's device), optimal, and superoptimal (peak PIFR ≥ 90 L/min).
View Article and Find Full Text PDFThis study determined whether compared to conventional mechanical ventilation (MV), extracorporeal membrane oxygenation (ECMO) is associated with decreased hospital mortality or fibrotic changes in patients with COVID-19 acute respiratory distress syndrome. A cohort of 72 patients treated with ECMO and 390 with conventional MV were analyzed (February 2020-December 2021). A target trial was emulated comparing the treatment strategies of initiating ECMO vs no ECMO within 7 days of MV in patients with a PaO/FiO < 80 or a PaCO ≥ 60 mmHg.
View Article and Find Full Text PDFArticle Synopsis
- COPD is linked to an increased risk of lung cancer, but the impact of inhaled corticosteroids (ICS) on this risk is unclear, prompting a study to investigate the relationship between inhaler prescriptions and comorbidities in COPD patients.
- A retrospective analysis of over 63,000 COPD patients found no significant difference in lung cancer development among those using different types of inhalers; rather, factors like diffuse interstitial lung disease, comorbidity scores, and hospitalization rates were more impactful.
- The study concluded that lung cancer risk in COPD patients is more strongly influenced by existing health issues and hospitalization frequency than the type of inhaler prescribed.
Background: A suboptimal peak inspiratory flow rate (PIFR) in dry-powder inhaler (DPI) users can lead to insufficient therapeutic effects in the treatment of chronic obstructive pulmonary disease (COPD). However, few data on the prevalence of and factors associated with suboptimal PIFR in Korean patients with COPD are available.
Methods: We conducted a cross-sectional study of patients with COPD who had been using DPIs for more than three months.
Background: COPD coexists with many concurrent comorbidities. Cardiovascular complications are deemed to be major causes of death in COPD. Although inhaler therapy is the main therapeutic intervention in COPD, cardiovascular events accompanying inhaler therapy require further investigation.
View Article and Find Full Text PDFBackground: Exercise capacity is associated with lung function decline in chronic obstructive pulmonary disease (COPD) patients, but a discrepancy between exercise capacity and airflow limitation exists. This study aimed to explore factors contributing to this discrepancy in COPD patients.
Methods: Data for this prospective study were obtained from the Korean COPD Subgroup Study.
Background: Rheumatoid arthritis-associated interstitial lung disease (RA-ILD) is a common extra-articular clinical manifestation of rheumatoid arthritis (RA) that has negative impacts on morbidity and mortality. In addition, there has been no proven treatment for RA-ILD to date. Thus, we planned a meta-analysis of a literature search to confirm the clinical effects of antifibrotic agents in RA-ILD patients.
View Article and Find Full Text PDFDiscontinuing mechanical ventilation remains challenging. We developed a machine learning model to predict weaning outcomes using only continuous monitoring parameters obtained from ventilators during spontaneous breathing trials (SBTs). Patients who received mechanical ventilation in the medical intensive care unit at a tertiary university hospital from 2019-2021 were included in this study.
View Article and Find Full Text PDFPurpose: To address the limited utility of the interferon (IFN)-γ release assay (IGRA) caused by its variability and inconsistency.
Methods: This retrospective cohort study was based on data obtained between 2011 and 2019. QuantiFERON-TB Gold-In-Tube was used to measure IFN-γ levels in nil, tuberculosis (TB) antigen, and mitogen tubes.
The Impact of Inhaled Corticosteroids on the Prognosis of Chronic Obstructive Pulmonary Disease.
Int J Chron Obstruct Pulmon Dis
May 2023
Background: A comprehensive analysis of the effects of inhaled corticosteroids (ICS) on COPD in a real-world setting is required due to safety concerns regarding ICS in COPD. This study aimed to explore the impact of ICS on the prognosis of Asian COPD patients in the real-life world.
Methods: We examined 978 COPD patients registered in the Korean National Health and Nutrition Examination Survey (KNHANES) database and with their data linked to Health Insurance and Review Assessment (HIRA) data.
Article Synopsis
- Recent reports indicate that pneumonitis may be a rare complication following SARS-CoV-2 vaccinations, with this study aiming to clarify its clinical features and outcomes.
- A nationwide survey identified 49 cases of vaccine-associated pneumonitis, with most patients being male and a median age of 66 years; symptoms typically manifested within 5 days post-vaccination.
- Although many patients saw improvement with corticosteroid treatment, 20% experienced worsening symptoms, and there was an observed mortality rate of 17%.
We evaluated whether the pathogens identified during acute exacerbation of chronic obstructive pulmonary disease (AE-COPD) are associated with the COPD medications used in the 6 months before AE-COPD. We collected the medical records of patients diagnosed with AE-COPD at 28 hospitals between January 2008 and December 2019 and retrospectively analyzed them. Microorganisms identified at the time of AE-COPD were analyzed according to the use of inhaled corticosteroid (ICS) and systemic steroid after adjusting for COPD severity.
View Article and Find Full Text PDFBackground: This study aimed to investigate the association between e-cigarette (EC) use and development of acute severe pneumonia in the Korean population using a national database.
Methods: We conducted a retrospective analysis using linkage of data between the Korean National Health and Nutrition Examination Survey (KNHANES) and the National Health Insurance Service (NHIS) administrative claims database. The primary endpoint of this study was development of severe pneumonia requiring hospital admission according to EC use during the study period.
Background: Although respiratory tract infection is one of the most important factors triggering acute exacerbation of chronic obstructive pulmonary disease (AE-COPD), limited data are available to suggest an epidemiologic pattern of microbiology in South Korea.
Methods: A multicenter observational study was conducted between January 2015 and December 2018 across 28 hospitals in South Korea. Adult patients with moderate-to-severe acute exacerbations of COPD were eligible to participate in the present study.
Interferon-γ-Inducible Chemokines as Prognostic Markers for Lung Cancer.
Int J Environ Res Public Health
September 2021
Interferon (IFN)-γ-inducible chemokines in the CXCR3/ligand axis are involved in cell-mediated immunity and play a significant role in the progression of cancer. We enrolled patients with lung cancer ( = 144) and healthy volunteers as the controls ( = 140). Initial blood samples were collected and concentrations of IFN-γ and IFN-γ-inducible chemokines CXCL9, CXCL10, and CXCL11 were measured using enzyme-linked immunosorbent assay.
View Article and Find Full Text PDFBiosignal-Based Digital Biomarkers for Prediction of Ventilator Weaning Success.
Int J Environ Res Public Health
September 2021
Article Synopsis
- The study focused on predicting the success of weaning patients from mechanical ventilation by analyzing new biosignal features from 89 intensive care unit patients.
- Researchers collected continuous data from various sources, including ECG and PPG, during a spontaneous breathing trial to compare signals between patients who successfully weaned from mechanical ventilation and those who did not.
- A machine learning model was developed to evaluate these biosignals, achieving a promising accuracy with an area under the curve of 0.81, suggesting it could help clinicians identify the best timing for extubation.
Background: This pilot study aimed to investigate the current status of e-cigarettes (ECs) use patterns among patients with chronic airway disease or chronic respiratory symptoms and the effects of ECs use on respiratory and mental health.
Methods: A cross-sectional survey was conducted at the outpatient clinic of eight teaching hospitals in South Korea between November 2019 and December 2019. All adult ECs users (19 years and above) who visited the outpatient clinic as a patient with chronic airway disease or chronic respiratory symptoms were eligible to participate in this study.
TB Antigen-Stimulated CXCR3 Ligand Assay for Diagnosis of Tuberculous Lymphadenitis.
Int J Environ Res Public Health
July 2021
The diagnosis of tuberculous lymphadenitis (TB-LAP) is challenging. We evaluated the role of blood CXC chemokine receptor 3 (CXCR3) ligands in its diagnosis. A total of 65 lymphadenopathy patients were enrolled and lymph node sampling was performed.
View Article and Find Full Text PDFBackground: E-cigarettes are steadily gaining popularity in Korea. However, the characteristics of e-cigarette smokers, especially nicotine dependence and stress susceptibility, have not been evaluated in comparison to those of non-smokers or combustible cigarette smokers in Korea.
Methods: In this study, 28,059 participants from the Korea National Health and Nutrition Examination Survey (2013-2017) were classified into the following three groups: non-smokers, smokers (current smokers and ex-smokers of combustible cigarettes only), and e-smokers (current smokers and ex-smokers of e-cigarettes regardless of combustible cigarette use).
Background: Low body mass index (BMI) is an important prognostic factor in chronic obstructive pulmonary disease (COPD). However, the prognostic value of longitudinal BMI change in COPD has not been well studied.
Objective: We aimed to evaluate the association between longitudinal change of BMI and prognosis of COPD in Korean COPD cohort.