PAK1 as a Potential Therapeutic Target in Male Smokers with EGFR-Mutant Non-Small Cell Lung Cancer.

P21-activated kinases (PAKs) are serine/threonine protein kinases that contribute to several cellular processes. Here, we aimed to determine the prognostic value of PAK1 and its correlation with the clinicopathological characteristics and five-year survival rates in patients with non-small cell lung cancer (NSCLC). We evaluated PAK1 mRNA and protein expression in NSCLC cells and resected tumor specimens, as well as in healthy human bronchial epithelial cells and adjacent healthy lung tissues, respectively, for effective comparison.

Successful treatment of catamenial hemoptysis by single-incision thoracoscopic left S9 + 10 segmentectomy using indocyanine green injection-assisted targeting.

Catamenial hemoptysis is a rare condition. A 28-year-old woman presented with a 1-year history of repetitive hemoptysis occurring on the first day of her menstrual period. Chest computed tomography revealed catamenial hemoptysis during her menstrual period.

Successful use of an EZ-blocker for lung isolation and management in a hemoptysis patient.

When massive hemoptysis develops suddenly, patients typically die due to hypovolemia or airway obstruction. Intubation, endobronchial blocking, and elimination of blood clots are urgently required. However, existing double-lumen tubes and single endobronchial balloon systems are inadequate.

Hybrid surgical resection of a tumor invading the superior vena cava.

Recently, hybrid operations featuring vascular interventions have become more common, but applications in the thoracic surgery are few. Superior vena cava (SVC) resection and reconstruction is a typical complex thoracic surgery. Traditional SVC resection/reconstruction requires advanced vascular surgical skills.

Bronchoesophageal fistula secondary to postpneumonectomy like syndrome caused by bilobectomy and postoperative radiation therapy for lung cancer.

Postpneumonectomy like syndrome is a very rare condition and benign bronchoesophageal fistula (BEF) is also uncommon in the adult. Therefore, the probability of occurrence of BEF secondary to postpneumonectomy like syndrome will be extremely rare, and has not been reported yet in the literature. This is the first case report of postpneumonectomy like syndrome combined BEF after bilobectomy and postoperative radiation therapy for lung cancer.

Is severe re-expansion pulmonary edema still a lethal complication of closed thoracostomy or thoracic surgery?

Background: Re-expansion pulmonary edema (REPE) is a lethal complication that can occur after inserting a chest tube. However, no clinical research reports have analyzed the progress and treatment of REPE, except for a single case report review. We retrospectively analyzed the common clinical characteristics, clinical progress, and treatment outcome of REPE with respiratory failure.

Non-intubated thoracoscopic bullectomy under sedation is safe and comfortable in the perioperative period.

Background: Non-intubated thoracoscopic surgery can be performed under sedation using adjuvant regional anesthesia, however, the benefits of non-intubated thoracoscopic surgery under sedation have not yet been completely verified. In this study, we compare the perioperative safety and pain complaints of sedation without intubation in thoracoscopic bullectomy with that of conventional general anesthesia with double-lumen intubation and mechanical ventilation.

Methods: Forty-one patients with primary spontaneous pneumothorax who were scheduled for thoracoscopic bullectomy were enrolled in this study.

The effect of ketamine on the incidence of emergence agitation in children undergoing tonsillectomy and adenoidectomy under sevoflurane general anesthesia.

Background: The rapid emergence and recovery from general anesthesia afforded by sevoflurane is associated with a high incidence of emergence agitation in children. Small doses of ketamine reduce the incidence of emergence agitation. This study compared the effects of ketamine 0.

Anaphylaxis with angioedema by rocuronium during induction of general anesthesia -A case report-.

Perioperative anaphylaxis is characterized by severe respiratory and cardiovascular manifestations. Correct management of anaphylaxis during anaesthesia requires a multidisciplinary approach with prompt recognition and treatment of the acute event by the attending anesthesiologist. A 34-year-old woman was scheduled to undergo endo venous laser therapy of varicose veins.

Anesthetic management in pediatric patient with Angelman syndrome: A case report.

The Angelman syndrome is characterized by an abnormality of chromosome 15, where a subunit of the gamma amino-butyric acid receptor is coded. The clinical features are developmental delay, microcephaly, wide mouth, prognathia which usually do not have problem with intubation. But, muscular atrophy may induce delayed recovery from neuromuscular blockade.