Publications by authors named "Jonnathan P Marin-Toledo"
Article Synopsis
- Previous attempts at creating safer antifungal treatments were based on an outdated model, focusing on how they damage fungal cell membranes.
- Researchers discovered that the key to the antifungal action of amphotericin B, a potent but kidney-damaging drug, lies in its ability to form sponge-like aggregates that extract crucial components from fungi.
- By modifying amphotericin B to selectively extract ergosterol without harming human kidneys, scientists developed a new polyene compound, AM-2-19, which shows promise as a safer and effective treatment against various fungal infections.
