Symptomatic rebound methaemoglobinaemia after treatment with dapsone.

A 28-year-old female patient was admitted to our hospital with severe dyspnoea and hypoxemia due to methaemoglobinaemia caused by dapsone. The patient recovered completely after repeated infusions of methylene blue and cessation of dapsone. However, 12 days after cessation of dapsone, the patient was readmitted due to recurrence of symptoms based on a relapse of methaemoglobinaemia.

Transcardial perfusion fixation of the CNS by means of a compressed-air-driven device.

In the present report we describe the construction of a systemic vascular perfusion device designed to perfuse small mammals with fixatives under a constant, controlled hydrostatic pressure. The device is powered by compressed-air. The construction of the device allows the interchange of vessels containing various perfusates during the perfusion, without having to interrupt the flow or alter the hydrostatic pressure.