Publications by authors named "Jongseung Baek"
Article Synopsis
- CCN1/Cyr61 is a key protein involved in bone maintenance, with studies showing its absence leads to reduced bone mass due to increased sclerostin levels that inhibit Wnt signaling.
- Research reveals that osteoblasts lacking CCN1 show impaired response to parathyroid hormone (PTH), which is normally involved in bone growth, due to decreased expression of the PTH receptor.
- The study highlights that a specific region of CCN1 that interacts with certain integrins is essential for activating PTH signaling, suggesting that this interaction plays a crucial role in bone cell function.
The type I TGFβ receptor TGFβRI (encoded by ) was ablated in cartilage. The resulting mice exhibited lethal chondrodysplasia. Similar defects were not seen in mice lacking the type II TGFβ receptor or SMADs 2 and 3, the intracellular mediators of canonical TGFβ signaling.
View Article and Find Full Text PDFCYR61/CCN1 is a matricellular protein that resides in the extracellular matrix, but serves regulatory rather than structural roles. CYR61/CCN1 is found in mineralized tissues and has been shown to influence bone healing in vivo and osteogenic differentiation in vitro. In this study we generated Cyr61 bone-specific knockout mice to examine the physiological role of CYR61/CCN1 in bone development and maintenance in vivo.
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