Successful management of suspected minoxidil toxicosis in a cat following accidental dermal exposure.

Minoxidil was originally introduced as a potent vasodilator, but is now widely used as a topical treatment for human alopecia. A 4-year-old neutered male Norwegian Forest cat presented with a 2-day history of anorexia, lethargy, and dyspnoea. A physical examination revealed hypothermia, tachypnoea, hypotension, and bilateral pulmonary crackles.

Spatially Ordered Arrays of Colloidal Inorganic Metal Halide Perovskite Nanocrystals via Controlled Droplet Evaporation in a Confined Geometry.

Inorganic metal halide perovskite nanocrystals, such as quantum dots (QDs), have emerged as intriguing building blocks for miniaturized light-emitting and optoelectronic devices. Although conventional lithographic approaches and printing techniques allow for discrete patterning at the micro/nanoscale, it is still important to utilize intrinsic QDs with the concomitant retaining of physical and chemical stability during the fabrication process. Here, we report a simple strategy for the evaporative self-assembly to produce highly ordered structures of CsPbBr and CsPbI QDs on a substrate in a precisely controllable manner by using a capillary-bridged restrict geometry.

Neuroprotective effects of systemic cerebral endothelial cell transplantation in a rat model of cerebral ischemia.

Human cerebral microvascular endothelial cell line (hCMEC)/D3 cells, which are from a stable clonal cell line of human immortalized cerebral endothelial cells, were intra-arterially transplanted through the common carotid artery in a rat model of photochemical-induced cerebral ischemia. Their therapeutic effects on infarct size, blood-brain barrier (BBB) breakdown, and outcome were examined. The hCMEC/D3 cells were genetically modified with the firefly luciferase gene for in vivo imaging post-transplantation.

A study of experimental autoimmune encephalomyelitis in dogs as a disease model for canine necrotizing encephalitis.

In the present study, the use of dogs with experimental autoimmune encephalomyelitis (EAE) as a disease model for necrotizing encephalitis (NE) was assessed. Twelve healthy dogs were included in this study. Canine forebrain tissues (8 g), including white and grey matter, were homogenized with 4 mL of phosphate-buffered saline for 5 min in an ice bath.

Canine model of ischemic stroke with permanent middle cerebral artery occlusion: clinical features, magnetic resonance imaging, histopathology, and immunohistochemistry.

The purpose of this study was to identify time-related changes in clinical, MRI, histopathologic, and immunohistochemical findings associated with ischemic stroke in dogs. Additionally, the association of cerebrospinal fluid (CSF) and tissue levels of interleukin (IL)-6 with clinical prognosis was assessed. Ischemic stroke was induced by permanent middle cerebral artery occlusion (MCAO) in nine healthy experimental dogs.

Imatinib mesylate plus hydroxyurea chemotherapy for cerebellar meningioma in a Belgian Malinois dog.

An 8-year-old intact male Belgian Malinois, weighing 37.2 kg, was referred for evaluation due to right side facial paresis, ataxia and a 2-month history of decreased cognitive ability. Physical and neurological examinations revealed mild depression, left-sided head tilt, right-sided facial paresis and ataxia.

A case of gastric adenocarcinoma in a Shih Tzu dog: successful treatment of early gastric cancer.

A 9-year-old castrated male Shih Tzu dog was referred to us, because of chronic vomiting. The patient's hematological, radiographic, ultrasonographic, endoscopic and histological examinations were evaluated for diagnosis. Hematologic analysis indicated moderate anemia and azotemia.

Unsuccessful cyclosporine plus prednisolone therapy for autoimmune meningoencephalitis in three dogs.

A 4-year-old female Maltese (case 1), a 9-year-old castrated male shih tzu (case 2) and 2-year-old female Pomeranian (case 3) presented with neurological signs, such as head tilt, ataxia, circling and paresis. The three cases were tentatively diagnosed as having meningoencephalitis of unknown etiology based on computed tomography scan and cerebrospinal fluid analysis. All patients were managed with cyclosporine plus prednisolone therapy.

Clinical characteristics and outcomes of primary adrenal hemangioma in a dog.

An 8-year-old 7.9 kg castrated male Shih-tzu dog was presented to surgery with polyuria-polydipsia, intermittent abdominal pain and dermatological problems. The unilateral enlargement of the right adrenal gland was observed through ultrasound examination and based on this examination a hyperadrenocorticism was suspected.

Brown alga Ecklonia cava attenuates type 1 diabetes by activating AMPK and Akt signaling pathways.

The antidiabetic therapeutic effect of Ecklonia cava, a brown alga, was investigated using streptozotocin-induced type 1 diabetes mellitus rats and C2C12 myoblasts. The methanol extract of E. cava (ECM), having a strong radical scavenging activity, significantly reduced plasma glucose level and increased insulin concentration in type 1 diabetes mellitus rats.