Competitive organizational climate and artificial intelligence (AI) acceptance: the moderating role of leaders' power construal.

Introduction: The incorporation of Artificial Intelligence (AI) in organizations is pivotal to deal with work-related tasks and challenges effectively, yet little is known about the organizational factors that influence AI acceptance (i.e., employee favorable AI attitudes and AI use).

Time-resolved dynamic disability adjusted life-years estimation.

The quantification of how healthy the indoor air is, is a complex issue comprising of a large number of contaminants of various sources. The health implication of exposure to each of the contaminant deemed of importance can be expressed using Disability Adjusted Life Years (DALYs). The sum of all DALYs indicates how harmful the indoor air was during the investigated time-frame.

A Personalized Neoantigen Vaccine in Combination with Platinum-Based Chemotherapy Induces a T-Cell Response Coinciding with a Complete Response in Endometrial Carcinoma.

Endometrial cancer (EC) is a common gynecological malignancy and the fourth most common malignancy in European and North American women. Amongst EC, the advanced serous, p53-mutated, and pMMR subtypes have the highest risk of relapse despite optimal standard of care therapy. At present, there is no standard of care maintenance treatment to prevent relapse among these high-risk patients.

Inflammatory B cells correlate with failure to checkpoint blockade in melanoma patients.

The understanding of the role of B cells in patients with solid tumors remains insufficient. We found that circulating B cells produced TNFα and/or IL-6, associated with unresponsiveness and poor overall survival of melanoma patients treated with anti-CTLA4 antibody. Transcriptome analysis of B cells from melanoma metastases showed enriched expression of inflammatory response genes.

Compliance to Screening Protocols for Multidrug-Resistant Microorganisms at the Emergency Departments of Two Academic Hospitals in the Dutch-German Cross-Border Region.

Infections caused by multidrug-resistant organisms (MDROs) are associated with prolonged hospitalization and higher risk of mortality. Patients arriving in the hospital via the emergency department (ED) are screened for the presence of MDROs in compliance with the screening protocols in order to apply the correct isolation measures. In the Dutch-German border region, local hospitals apply their own screening protocols which are based upon national screening protocols.

Integrated Home- and Community-Based Services Improve Community Survival Among Independence at Home Medicare Beneficiaries Without Increasing Medicaid Costs.

Objectives: To determine the effect of home-based primary care (HBPC) for frail older adults, operating under Independence at Home (IAH) incentive alignment on long-term institutionalization (LTI).

Design: Case-cohort study using HBPC site, Medicare administrative data, and National Health and Aging Trends Study (NHATS) benchmarks.

Setting: Three IAH-participating HBPC sites in Philadelphia, PA, Richmond, VA, and Washington, DC.

Lymphatic vessel density is associated with CD8 T cell infiltration and immunosuppressive factors in human melanoma.

Increased density of tumor-associated lymphatic vessels correlates with poor patient survival in melanoma and other cancers, yet lymphatic drainage is essential for initiating an immune response. Here we asked whether and how lymphatic vessel density (LVD) correlates with immune cell infiltration in primary tumors and lymph nodes (LNs) from patients with cutaneous melanoma. Using immunohistochemistry and quantitative image analysis, we found significant positive correlations between LVD and CD8 T cell infiltration as well as expression of the immunosuppressive molecules inducible nitric oxide synthase (iNOS) and 2,3-dioxygénase (IDO).

STAT6 Mediates Footpad Immunopathology in the Absence of IL-12p40 Following Infection of Susceptible BALB/c Mice With .

() parasites are intracellular parasites belong to the family and are the causative agent of cutaneous leishmaniasis. This disease affects approximately 1.5 million per year worldwide and there is currently no prophylactic vaccine available.

Stimulated by Novelty? The Role of Psychological Needs and Perceived Creativity.

In the current research, we aimed to address the inconsistent finding in the brainstorming literature that cognitive stimulation sometimes results from novel input, yet other times from non-novel input. We expected and found, in three experiments, that the strength and valence of this relationship are moderated by people's psychological needs for structure and autonomy. Specifically, the effect of novel input (vs.

Simultaneous enumeration of cancer and immune cell types from bulk tumor gene expression data.

Immune cells infiltrating tumors can have important impact on tumor progression and response to therapy. We present an efficient algorithm to simultaneously estimate the fraction of cancer and immune cell types from bulk tumor gene expression data. Our method integrates novel gene expression profiles from each major non-malignant cell type found in tumors, renormalization based on cell-type-specific mRNA content, and the ability to consider uncharacterized and possibly highly variable cell types.

Effects of home-based primary care on Medicare costs in high-risk elders.

Objectives: To determine the effect of home-based primary care (HBPC) on Medicare costs and mortality in frail elders.

Design: Case-control concurrent study using Medicare administrative data.

Setting: HBPC practice in Washington, District of Columbia.

Blended working: for whom it may (not) work.

Similarly to related developments such as blended learning and blended care, blended working is a pervasive and booming trend in modern societies. Blended working combines on-site and off-site working in an optimal way to improve workers' and organizations' outcomes. In this paper, we examine the degree to which workers feel that the two defining features of blended working (i.

A reliable test to detect impending pump failure during long-term support on the Novacor N100 Left Ventricular Assist System.

The Durastudy is a new surveillance protocol to detect impending pump failure in Novacor N100 Left Ventricular Assist Systems implanted for the long term. Our patient, a 54-year-old man with a history of dilated cardiomyopathy and contraindications for heart transplantation, received a Novacor pump in May 1995 and did not experience sustainable ventricular recovery during the subsequent 3 years. After more than 3 years of support, symptoms of pump wear were detected in this patient, through application of the Durastudy protocol.

Diagnosis and management of left ventricular assist device valve-endocarditis: LVAD valve replacement.

A 57-year-old man who has been wearing a Novacor N100 left ventricular assist device (LVAD) for more than 3 years suffered from LVAD endocarditis. Only by immunoscintigraphic methods was it possible to localize the septic focus. After successful exchange of in- and outflow tract valves, the infection was eradicated.

The timing of do-not-resuscitate orders and hospital costs.

The relation between the timing of do-not-resuscitate (DNR) orders and the cost of medical care is not well understood. This prospective observational study compares hospital costs and length of stay of 265 terminally ill patients with admission DNR orders, delayed DNR orders (occurring after 24 hours), or no DNR orders (full code). Patients whose orders remained full code throughout a hospital stay had similar lengths of stay, total hospital costs, and daily costs as patients with admission DNR orders.

[Potentiation of digoxin by itraconazole].

The case is reported of a 71-year-old woman with clinical signs of digoxin intoxication, presumably developing as a result of the simultaneous use of digoxin for cardiac abnormalities and itraconazole for infection with Candida albicans. Five similar experiences have previously been reported in the literature. Itraconazole may induce a decreased elimination of digoxin, but the mechanism of interaction is still unknown.

Theta replication of the lactococcal plasmid pWVO2.

pWVO2 is a 3.8 kb narrow-host-range plasmid from Lactococcus lactis ssp. cremoris Wg2, which does not replicate in Bacillus subtilis or Escherichia coli.

Theta replication of the lactococcal plasmid pWVO2.

pWVO2 is a 3.8 kb narrow-host-range plasmid from Lactococcus lactis ssp. cremoris Wg2, which does not replicate in Bacillus subtilis or Escherichia coli.

Identification with liquid chromatography-ionspray mass spectrometry of the metabolites of the enantiomers N-methyl dextrorphan and N-methyl levorphanol after rat liver perfusion.

To gather more information on stereochemical factors in the hepatic disposition of organic cations, mass spectrometry coupled to liquid chromatography was used to determine the identity of the metabolites excreted in bile after isolated rat liver perfusions with the quaternary ammonium derivatives of the enantiomeric drugs dextrorphan and levorphanol. Ionspray mass spectrometry was chosen for its soft ionization and absence of thermal degradation of labile compounds. The drugs were labelled with a stable (2H) isotope and mixed with unlabelled drugs to create an artificial isotope pattern in the mass spectrum and facilitate the recognition of unknown metabolites.

[Measuring model for intraoperative determination of vascular resistance in crural vascular surgery].

The measurement of the vascular outflow resistance during reconstructive vascular operations was applied since 1989 on 45 subjects with reliable results. This measurement is an aid for decision of additional treatment increasing the outflow, like a jump- or sequential bypass or a pharmacological therapy. The principle of measurement is based on the injection of a known volume of saline in the vessel and the integration of the intravascular pressure during this injection.

Food consumption of children with and without xerophthalmia in rural Tanzania.

Food intake of 26 children (4-9 years old) of whom nine had xerophthalmic eye lesions (Bitot's spots), was recorded over a period of four days. The principal staple foods were maize and sweet potatoes, while sorghum and cassava were also used as staple foods. The intake of energy was rather low partly due to the bulkiness of the diet.

Late results following extra-anatomic bypass procedures for chronic aortoiliac occlusive disease.

During the period from 1970 to 1983 150 extra-anatomic bypass operations were carried out on 129 high risk patients revascularizing 157 extremities. There were 124 axillofemoral and 26 femorofemoral bypass grafts. In elective operations the mortality ranged from 4.