Publications by authors named "Jong Jeong"

Long-term allograft survival is limited by humoral-associated chronic allograft rejection, suggesting inadequate constraint of humoral alloimmunity by contemporary immunosuppression. Heterogeneity in alloreactive B cells and the incomplete definition of which B cells participate in chronic rejection in immunosuppressed transplant recipients limits our ability to develop effective therapies. Using a double-fluorochrome single-HLA tetramer approach combined with single-cell culture, we investigated the B-cell receptor (BCR) repertoire characteristics, avidity, and phenotype of donor HLA-DQ reactive B cells in a transplant recipient with end-stage donor specific antibody (DSA)-associated cardiac allograft vasculopathy while receiving maintenance immunosuppression (tacrolimus, mycophenolate mofetil, prednisone).

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Isoflavone-enriched soybean leaves (IESLs) were processed for drying, steaming, and fermentation, and bioactive compounds and biological activities were analyzed. During food processing, the content of fatty acids, water-soluble vitamins, total phenolics, total flavonoids, and isoflavone-aglycones increased from dried IESLs (DrIESLs) to fermented IESLs (FeIESLs). Especially, oleic acid (53.

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  • * Researchers analyzed clinical data from 669 patients admitted to the ICU, finding that 27.8% developed new frailty at discharge, with factors like older age and certain health conditions linked to this change.
  • * The findings indicate that new frailty is relatively common in these patients and is associated with various health factors, highlighting the need for better post-hospital care.
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Background: Decreased lean body mass or muscle mass is associated with decreased bone mineral density in individuals with preserved renal function. However, the association between muscle mass and bone mineral density in chronic kidney disease (CKD) patients is not well known. The aim of this study was to assess the relationship between muscle mass estimated from urine creatinine (UCr) and bone mineral density in Korean CKD patients.

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  • Primary graft dysfunction (PGD) and chronic lung allograft dysfunction (CLAD) are the main reasons lung transplants fail, and research using mouse models is helping to understand the specific biological pathways involved.
  • Recent studies have identified key immune cells and their interactions that contribute to PGD and CLAD, including the role of different types of monocytes, neutrophils, and T cells.
  • There is an urgent need for better targeted treatments to manage PGD and CLAD, and ongoing research is revealing new potential prevention and treatment strategies for lung transplant recipients.
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  • This study analyzed the nutrients and antioxidant activities of different ratios (0%, 2.5%, 5%, and 10%) of mountain-cultivated ginseng (MCG) fermented with specific microorganisms.
  • It found that fermentation altered the content of isoflavones and ginsenosides, generally decreasing certain types while increasing others, particularly beneficial compounds like ginsenoside Rg3 and compound K.
  • The results suggest that higher ratios of MCG enhance the overall quality, antioxidant properties, and potential health benefits, making it valuable for food and pharmaceutical uses.
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  • - The study examined the relationship between nutritional intake, physical activity (PA), and handgrip strength (HGS) in individuals over 40 with airflow limitation, using data from the 2014 to 2016 Korean National Health and Nutrition Examination Survey.
  • - Results indicated that those who were more physically active and had higher HGS reported greater intakes of food, calories, water, protein, and lipids, with strong correlations found between protein and caloric intake and HGS.
  • - Ultimately, while significant connections were observed, the study concluded that nutritional intake did not serve as an independent factor influencing PA and HGS, suggesting potential indirect effects worth exploring further.
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In this study, we investigated the effects of different nitrite sources (sodium nitrite or white kimchi powder) and pink-generating ligands (cysteine, histidine, or nicotinamide) on the development and stability of cured meat color in pork sausage model systems over 30 d of refrigerated storage. The samples were prepared in a 2 × 3 factorial design with two nitrite sources and three ligands, and their physicochemical properties were evaluated on days 0, 15, and 30. Although white kimchi powder induced cured color development similar to that of synthetic sodium nitrite, it resulted in higher cooking loss and lower residual nitrite content in cured pork sausages ( < 0.

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Advances in next-generation sequencing technologies have led to elucidation of sensorineural hearing loss genetics and associated clinical impacts. However, studies on the functional pathogenicity of variants of uncertain significance (VUS), despite their close association with clinical phenotypes, are lacking. Here we identified compound heterozygous variants in ESRRB transcription factor gene linked to DFNB35, specifically a novel splicing variant (NM_004452.

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This study investigated the potential of Chinese cabbage and radish powders as natural sources of nitrite in ground pork sausages. Four vegetable powders from Chinese cabbage and radish, depending on the processing method, were prepared for evaluation: filtered Chinese cabbage juice powder (FCJP), crushed Chinese cabbage powder (CCP), filtered radish juice powder (FRJP), and crushed radish powder (CRP). Both FCJP and FRJP from filtered juice of Chinese cabbages and radishes had higher total soluble solids and water soluble index compared to CCP and CRP from crushed Chinese cabbages and radishes.

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Background: Living kidney donors with hypertension are potential candidates for solving the donor shortages in renal transplantation. However, the safety of donors with hypertension after nephrectomy has not been sufficiently confirmed.

Methods: A total of 642 hypertensive and 4,848 normotensive living kidney donors who were enrolled in the Korean Organ Transplantation Registry between May 2014 and December 2020 were included in this study.

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Introduction: Kidney transplantation (KT) improves the cardiovascular outcomes of patients with end-stage kidney disease. However, cardiovascular disease remains the leading cause of premature death and graft loss in KT recipients (KTRs) with diabetes. We evaluated the cardioprotective effects of sodium-glucose cotransporter 2 inhibitors (SGLT2i) in KTRs with diabetes.

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  • - This study examined how solid-state fermentation with various fungi affects the nutritional components, isoflavones, and antioxidant activities of Apios americana Medikus (AAM), highlighting significant increases in fatty acid and amino acid content post-fermentation.
  • - The fermentation process, particularly with the fungus Monascus purpureus, resulted in a remarkable increase in total fatty acids (up to 26.3 times) and improved mineral contents, demonstrating notable nutritional enhancement.
  • - Isoflavone glycosides in unfermented AAM were converted to more beneficial aglycone forms during fermentation, leading to higher total phenolic and flavonoid contents, which suggests that fermented AAM could be a valuable ingredient for food and medicinal
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  • - The study investigates the effects of coronary artery calcification score (CACS) and abdominal aortic calcification score (AACS) on cardiovascular and renal outcomes in kidney transplant patients, which have not been thoroughly examined before.
  • - It categorizes 944 kidney transplant recipients into low, medium, and high groups based on their CACS and AACS, with the primary focus on cardiovascular events and secondary outcomes like all-cause mortality and kidney function decline.
  • - The results show that patients in the high CACS and AACS groups had significantly higher risks for cardiovascular events and all-cause mortality, but there was no notable difference in renal outcomes across the groups.
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Background: Chronic kidney disease (CKD) patients are hospitalized for various conditions. Hospitalization increases the readmission rate and mortality rate, seriously deteriorating patients' quality of life. Consequently, it is crucial to analyze the reasons for hospitalization in CKD patients from a broader perspective according to CKD grade.

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Purpose: Thyroid cancer incidence has increased in recent decades, and thyroid surgery is continuously evolving in response to demands for postoperative comfort and cosmesis. This study aimed to introduce a new surgical method for minimally invasive open bilateral total thyroidectomy (MI-BTT) using a unilateral 2.5-3.

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  • - The study examines the usefulness of age-adjusted endothelial activation and stress index (age-EASIX) in predicting ICU mortality for critically ill COVID-19 patients in South Korea, based on data from 22 hospitals from January 2020 to August 2021.
  • - It involved 908 patients, averaging 67.4 years old, with non-survivors showing a significantly higher log2 age-EASIX compared to survivors, indicating that age-EASIX correlates with ICU mortality risk.
  • - The findings suggest that age-EASIX not only is significantly linked to ICU mortality but also outperforms the sequential organ failure assessment (SOFA) score in predicting outcomes for patients in ICU.
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The use of natural ingredients in meat processing has recently gained considerable interest, as consumers are increasingly attracted to clean-label meat products. However, limited research has been conducted on the use of natural substitutes for synthetic phosphates in the production of clean-label meat products. Therefore, this study aimed to explore the potential of oyster shell powder as a substitute for synthetic phosphates in pork patties cured with Chinese cabbage or radish powders.

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  • * Researchers conducted a retrospective analysis of 24,626 patients, finding that the recurrence rate was significantly higher in patients with DSV than in those with conventional PTC (cPTC), particularly among pediatric patients.
  • * The findings suggest that pediatric patients with DSV face a greater recurrence risk than adults, revealing a unique age-related pattern of recurrence that differs from that observed in cPTC cases.
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Background: Previous study proposed a method to measure linear energy transfer (LET) at specific points using the quenching magnitude of thin film solar cells. This study was conducted to propose a more advanced method for measuring the LET distribution.

Purpose: This study focuses on evaluating the feasibility of estimating the proton LET distribution in proton therapy.

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Ribonucleotide Reductase (RNR) is a rate-limiting enzyme in the production of deoxyribonucleoside triphosphates (dNTPs), which are essential substrates for DNA repair after radiation damage. We explored the radiosensitization property of RNR and investigated a selective RRM2 inhibitor, 3-AP, as a radiosensitizer in the treatment of metastatic pNETs. We investigated the role of RNR subunit, RRM2, in pancreatic neuroendocrine (pNET) cells and responses to radiation in vitro.

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The current research was the first to prove the existence of fluctuations in the metabolite constituents and antioxidant properties in different organs (leaves, stems, and roots) of the mountain-cultivated ginseng (MCG) plant during a two-month maturation period. Four metabolites, including fatty acids, amino acids, ginsenosides, and phenolic phytochemicals, exhibited considerable differences in organs and maturation times with the following order: leaves > stems > roots. The predominant metabolite contents were found in leaves, with fatty acid (1057.

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BACKGROUND According to the current guidelines for liver transplantation (LT) of brain-dead donors with hepatitis B or C virus (HBV or HCV) in Korea, grafts from hepatitis B surface antigen (HBsAg)(+) or HCV antibody (anti-HCV)(+) donors must be transplanted only to HBsAg(+) or anti-HCV(+) recipients, respectively. We aimed to determine the current status and outcomes of brain-dead donor LT with HBV or HCV in Korea. MATERIAL AND METHODS This retrospective observational study included all LTs from brain-dead donors in the Korean Organ Transplantation Registry between April 2014 and December 2020.

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Overexpression of human CD200 (hCD200) in porcine endothelial cells (PECs) has been reported to suppress xenogeneic immune responses of human macrophages against porcine endothelial cells. The current study aimed to address whether the above-mentioned beneficial effect of hCD200 is mediated by overcoming the molecular incompatibility between porcine CD200 (pCD200) and hCD200 receptor or simply by increasing the expression levels of CD200 without any molecular incompatibility across the two species. We overexpressed hCD200 or pCD200 using lentiviral vectors with V5 marker in porcine endothelial cells and compared their suppressive activity against U937-derived human macrophage-like cells (hMCs) and primary macrophages.

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