Impact of the COVID-19 pandemic on the diagnosis and management of primary cutaneous melanomas in New South Wales, Australia: A retrospective cohort study.

Background And Objectives: The COVID-19 pandemic caused upheaval of healthcare systems, with evolving consequences. The aim of this study was to evaluate the impact of the pandemic on melanoma diagnosis and management in New South Wales, Australia.

Method: In this retrospective cohort study, we analysed all new melanomas diagnosed at a tertiary care hospital over a three-year period.

Real-world data on the efficacy and safety of hedgehog pathway inhibitors in patients with basal cell carcinoma: Experience of a tertiary Australian centre.

Background: Basal cell carcinomas (BCCs) are the most common cancers worldwide. Although most BCCs are amenable to local treatment, there are limited therapeutic options for surgically unresectable locally advanced and metastatic BCCs. Activation of the sonic hedgehog signalling pathway plays a significant role in the development of most BCCs.

Responsiveness of the Spanish Version of the "Skin Cancer Index".

Skin Cancer Index (SCI) is a specific questionnaire measuring health related quality of life (HRQL) in patients with cervicofacial non-melanoma skin cancer (CFNMSC). The original scale has recently been adapted and validated into Spanish. Evaluate the responsiveness of the Spanish version of SCI.

Quality of life and side effects in patients with actinic keratosis treated with ingenol mebutate: a pilot study.

Introduction: Actinic keratosis (AK) lesions are in situ squamous cell carcinoma. These lesions have a low risk of progressing to invasive disease but significant impact on patients' quality of life (QoL). The aim of this study was to assess QoL and side effects in patients with AK receiving treatment with ingenol mebutate.

A Spanish version of the Skin Cancer Index: a questionnaire for measuring quality of life in patients with cervicofacial nonmelanoma skin cancer.

Introduction: The Skin Cancer Index (SCI) is the first specific patient-reported outcome measure for patients with cervicofacial nonmelanoma skin cancer. To date, only the original English version has been published.

Objectives: To develop a Spanish version of the SCI that is semantically and linguistically equivalent to the original, and to evaluate its measurement properties in this different cultural environment.

Comparison of Skindex-29, Dermatology Life Quality Index, Psoriasis Disability Index and Medical Outcome Study Short Form 36 in patients with mild to severe psoriasis.

Background: Severity assessment of patients with psoriasis is a critical issue. Classical clinical assessment has recently been combined with quality of life (QoL) scores, but several instruments are used. Moreover, studies have focused on patients with moderate to severe psoriasis.

Self-reported adherence to treatment and quality of life in mild to moderate acne.

Background: Adherence to treatment is a mayor issue in dermatology, and its relationship to quality of life has barely been studied.

Objective: To evaluate the relationship between scores on the Skindex-29 skin disease assessment scale and adherence to treatment in patients with acne.

Methods: An observational, prospective study of 1,628 patients carried out by 252 clinicians in Spain.

Use of biological agents in patients with moderate to severe psoriasis: a cohort-based perspective.

Objective: To compare characteristics of patients enrolled in a long-term multicenter cohort trial who had used biological therapies for treatment of psoriasis with those who had not used these agents.

Design: Retrospective analysis of users vs nonusers of biological therapies.

Setting: Database from the PUVA Follow-up Study, a multicenter, 30-year study of patients originally treated with psoralen UV-A (PUVA) for moderate to severe psoriasis.

Quality of life in mild to moderate acne: relationship to clinical severity and factors influencing change with treatment.

Background: Because of its effects on quality of life, acne vulgaris is more than a merely physiological or cosmetic entity.

Objectives: To describe the influence of mild to moderate acne on patients' quality of life, measured using Skindex-29, and to correlate changes in Skindex-29 scores with changes in objective and subjective indices in clinical severity after treatment with topical 4% erythromycin 0.2% zinc.

[Consensus document on phototherapy: PUVA therapy and narrow-band UVB therapy].

It is essential to develop a consensus document on phototherapy in order to adapt this procedure to the specific characteristics, needs and reality of our milieu. Using a review of existing literature on the subject and the experience of its own members as a reference, the Spanish Photobiology Group (GEF) of the Spanish Academy of Dermatology and Venereology (AEDV) has developed some therapeutic guidelines for the most widely used modes of phototherapy: PUVA therapy and narrow-band UVB (NBUVB) therapy. These guidelines deal with generalities about the equipment, calibration and regulation in phototherapy booths, and the concept and indications for these forms of treatment are reviewed.

Sclerodermatous graft-vs-host disease: clinical and pathological study of 17 patients.

Objective: To collect and review all cases of sclerodermatous chronic graft-vs-host disease from January 1, 1982, through December 31, 2000.

Setting: University hospital in Madrid, Spain.

Patients: During the study period, 493 allogenic bone marrow transplantations were performed.

[The Spanish version of Skindex-29. An instrument for measuring quality of life in patients with cutaneous diseases].

Background: Quality-of-life studies aim to measure objectively how patient life is affected by disease. Generation of a novel instrument is more expensive and time-consuming than adapting a test already existing in another language. Skindex-29 is a widely validated American instrument to measure quality of life in patients with cutaneous disease.

The Spanish version of Skindex-29.

Background: Most currently available dermatologic quality-of-life measures were originally created in English, and must be translated and adapted for use in other cultures. Our purpose was to translate and adapt culturally into Spanish a skin-related quality-of-life measure, Skindex-29, and to begin preliminary assessments of its reliability and validity.

Methods: Transcultural adaptation and cross-sectional questionnaire studies were performed.

Madelung's disease involving the tongue.

Madelung's disease or benign symmetric lipomatosis is rare. Symmetric lipomatosis of the tongue as an association of Madelung's disease is very rare; up to now only two cases of this association have been reported. We report the third case of Madelung's disease with involvement of the tongue in the form of macroglossia.

Sclerodermatous graft-versus-host disease after donor leucocyte infusion.

Leucocyte infusion from the marrow donor is a new therapeutic option to avoid repeated bone marrow transplants in patients with recurrent leukaemia. The treatment is based on the fact that alloreactive donor immune cells may recognize and eliminate residual leukaemia cells. This phenomenon has been called graft-versus-leukaemia.