Anesthetic considerations in mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes syndrome: a case series.

Purpose: Mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes syndrome (MELAS) is a rare inherited mitochondrial disorder associated with severe multiorgan pathology and stress-induced episodes of metabolic decompensation and lactic acidosis. The purpose of this case series is to review the medical records of patients with MELAS who underwent anesthetic care at the Mayo Clinic to observe their perioperative responses to anesthesia and to assess outcomes.

Principal Findings: From September 1997 to October 2010, nine patients with MELAS were identified who underwent 20 general anesthetics, 12 prior to MELAS diagnosis.

Effects of propofol on intraoperative parathyroid hormone monitoring in patients with primary hyperparathyroidism undergoing parathyroidectomy: a randomized control trial.

Purpose: Serial measurements of parathyroid hormone (PTH) serum concentrations aid parathyroidectomy surgery. There are concerns that propofol may increase PTH concentrations and/or interfere with PTH assays. The primary purpose of this study is to determine the effects of propofol on PTH concentrations in patients with primary hyperparathyroidism and to determine its effect on PTH assays.

Perioperative course and intraoperative temperatures in patients with osteogenesis imperfecta.

Background And Objectives: Concerns persist regarding the association of osteogenesis imperfecta with perioperative complications and intraoperative hyperpyrexia. The purpose of this study is to examine whether osteogenesis imperfecta patients develop intraoperative hyperthermia and to describe anaesthesia-related complications.

Methods: Medical records of 49 osteogenesis imperfecta patients undergoing 180 anaesthetics were reviewed for the presence of perioperative anaesthetic complications.

Anesthetic management of patients with Huntington disease.

Background: Huntington disease (HD) is a rare autosomal dominant disease with symptoms of chorea, dystonia, incoordination, cognitive decline, and behavioral difficulties. Abnormal responses to anesthesia have been reported in case reports and raised concerns regarding the safety of anesthesia in this patient population.

Methods: We performed a computerized search of the Mayo Clinic medical records database searching for patients with HD who underwent general anesthesia.

Two generalizable routes to terminal carbido complexes.

Desulfurization of the thiocarbonyl ligand in square pyramidal [Ru(CS)Cl2(PCy3)2] (1-S) via sulfur atom abstraction using [Mo(H)(eta2-Me2CNAr)(N[i-Pr]Ar)2] forms [Ru(C)Cl2(PCy3)2] (1) cleanly over several hours in benzene; isolated yield is 55%. Complex 1 is also formed in 87% isolated yield upon reaction of [Ru(CHR)(PCy3)2Cl2] (R = p-C6H4Me, 2; Ph, 3) with vinyl acetate in dichloromethane. Complex 1-S is re-formed quantitatively from 1 upon treatment with elemental sulfur in CH2Cl2, but is prepared most conveniently by treatment of crude [Ru(CS)Cl2(PPh3)2(OH2)] with excess PCy3 in toluene.