Publications by authors named "Jonathon Carl Arnold"
Article Synopsis
- * It found that using magnesium stearate improved aerosol performance and that the shape and size of the particles varied based on the type of inhaler used, with low-resistant inhalers resulting in higher throat deposition.
- * The optimal formulation was determined to be CBD powder with 5% magnesium stearate using a high-resistance inhaler, which showed promising results with the best fine particle fraction and minimal throat deposition, indicating potential for future in vivo testing.
Pulmonary delivery is an efficient route of administration to deliver cannabidiol (CBD) due to the high bioavailability and fast onset of action. The major formulation challenge is the poor aqueous solubility of CBD. This study aimed to produce inhalable CBD powders with enhanced solubility and characterise their solid-state properties.
View Article and Find Full Text PDFThe use of cannabidiol (CBD) for treating brain disorders has gained increasing interest. While the mechanism of action of CBD in these conditions is still under investigation, CBD has been shown to affect numerous different drug targets in the brain that are involved in brain disorders. Here we review the preclinical and clinical evidence on the potential therapeutic use of CBD in treating various brain disorders.
View Article and Find Full Text PDFDravet syndrome is an intractable pediatric epilepsy associated with SCN1A mutations. In addition to having a large seizure burden and a reduced lifespan, patients with Dravet syndrome also exhibit delays in reaching normal developmental milestones in attentional, emotional, and cognitive function. These developmental delays manifest in autistic-like social withdrawal and compulsive behavior.
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