Publications by authors named "Jonathon Bloor"
Article Synopsis
- This study investigates the connection between 8-isoprostane F(2α) (8-IPF(2α)) and erectile dysfunction (ED), highlighting how superoxide production from NADPH oxidase can lead to increased levels of 8-IPF(2α) and influence vascular function.
- Researchers incubated cavernosal vascular smooth muscle cells with various compounds including 8-IPF(2α) and assessed the resulting changes in superoxide levels and PDE5 expression.
- The results suggest that superoxide production is linked to ED through its impact on key vascular regulators, revealing a novel mechanism for sildenafil’s action in treating erectile dysfunction.
Aim: To study the effects of homocysteine and copper on type 5 phosphodiesterase (PDE5) expression in cavernosal vascular smooth muscle cells (CVSMCs) and to investigate superoxide (O(2)(.-)) derived from nicotinamide adenine dinucleotide phosphate oxidase as homocysteine and copper generate O(2)(.-), and O(2)(.
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