Publications by authors named "Jonathan Zijiang Yang"
Proc Natl Acad Sci U S A
April 2018
Article Synopsis
- The WNK signaling pathway plays a crucial role in regulating cell volume and ion transport through kinases SPAK and OSR1.
- SPAK and OSR1 interact with specific sequence motifs, including a variant that is present in some human inward rectifier K channels, which is essential for their activation.
- The study shows that OSR1 activates certain K channels (Kir2.1 and Kir2.3) but not others (like Kir4.1), and highlights the importance of the WNK-OSR1 pathway in enhancing the plasma membrane localization of these channels.
