Publications by authors named "Jonathan Y Bitton"
Article Synopsis
- Vigabatrin (VGB) is effective for treating Infantile Spasms (IS) in children, but its use should be limited due to potential toxicity, with an uncertain ideal treatment duration.
- A study of 44 infants who responded well to VGB found no relapses in spasms after 6 months of treatment, compared to those treated longer.
- The findings suggest that a 6-month course of VGB may adequately control spasms without significant development of late epilepsy, especially in patients with no identified cause for their condition.
Aim: To evaluate the long-term developmental trajectory of children with infantile spasms (IS) and identify the clinical protective and risk factors associated with their cognitive outcome.
Methods: We analyzed the five-year follow-up results of 41 children (13 female) from the previously published cohort (n = 68) recruited in a multicenter randomized controlled trial for 2-years, examining the effect of an adjunctive therapy (Flunarizine) on standardized IS treatment. The children were subsequently monitored in an open-label study for additional 3 years.
Background: Sturge-Weber syndrome is characterized by a facial port-wine stain associated with either or both a retinal angioma and a cerebral pial angioma. Because a pial angioma may not be evident on the initial imaging studies, individuals at risk for epilepsy are often not identified before their first seizure. The aim of this study is to identify predictive factors predisposing Sturge-Weber patients to epilepsy.
View Article and Find Full Text PDFObjective: Infantile spasms (IS) are a severe form of childhood epilepsy associated with autism spectrum disorders (ASD) in up to 35% of cases. The objective of this post hoc analysis of our randomized control trial was to determine whether rapid diagnosis and treatment of IS could limit the incidence of ASD while identifying risk factors related to ASD outcome.
Methods: Patients with IS were randomized in a standardized diagnostic and treatment protocol.
Purpose: Cognitive impairment is observed commonly in children with a history of infantile spasms (IS). The goal of this study was to prospectively examine the effect on cognitive outcome of a neuroprotective agent used as adjunctive therapy during treatment of the spasms.
Methods: In a randomized controlled trial, patients received a standardized therapy plus flunarizine or placebo.