Publications by authors named "Jonathan Wiseman"
Introduction: The decision to become a living donor requires consideration of a complex, interactive array of factors that could be targeted for clinical, policy, and educational interventions. Our objective was to assess how financial barriers interact with motivators, other barriers, and facilitators during this process.
Methods: Data were obtained from a public survey assessing motivators, barriers, and facilitators of living donation.
Purpose: We characterize patients with urinary urgency with vs without urgency urinary incontinence who presented to clinics actively seeking treatment for their symptoms.
Materials And Methods: Participants who enrolled in the Symptoms of Lower Urinary Tract Dysfunction Research Network were categorized into urinary urgency with vs without urgency urinary incontinence. Participants were followed for 1 year; their urinary symptoms, urological pain, psychosocial factors, bowel function, sleep disturbance, physical activity levels, physical function, and quality of life were compared.
Article Synopsis
- Bladder diaries are important for understanding lower urinary tract symptoms (LUTS), but many patients struggle to fill them out correctly.
- A study involving 290 symptomatic adults showed that while 60% completed the diaries, the strongest correlations between bladder diary data and patient-reported outcome measures (PROMs) were found for daytime (r=0.75) and nighttime frequency (r=0.69).
- Overall, while bladder diaries have limitations due to missing data, PROMs serve as a valid alternative, especially for tracking voiding frequency more conveniently.
Aims: Bother attributed to lower urinary tract symptoms (LUTS) drives care-seeking and treatment aggressiveness. The longitudinal relationship of LUTS severity and bother in a care-seeking cohort, however, is not well understood. We aim to conduct a longitudinal evaluation of LUTS severity and bother and identify characteristics of patients with discordant LUTS bother relative to severity.
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- The study aimed to assess how common and severe nocturia (nighttime urination) is among patients with lower urinary tract symptoms (LUTS), along with its correlates.
- Researchers had 502 patients track their nighttime urination for three days and categorized nocturia based on episodes, measuring the impact on their quality of sleep and bothersome effects.
- Results showed that nearly half of the patients experienced nocturia, with many reporting significant distress, and the most prevalent type being nocturnal polyuria, mainly affecting males and linked to worse sleep quality.
Aims: The aims of this study were to assess the completeness of voiding diaries in a research context and to correlate diary data with patient-reported questionnaires.
Methods: Men and women enrolled in the Symptoms of Lower Urinary Tract Dysfunction Research Network (LURN) were given a 3-day voiding and fluid-intake diary to fill-out. Diaries were assessed for completeness and intake-output imbalances.
Purpose: Conventional classification of patients with lower urinary tract symptoms into diagnostic categories based on a predefined symptom complex or predominant symptom appears inadequate. This is due to the frequent presentation of patients with multiple urinary symptoms which could not be perfectly categorized into traditional diagnostic groups. We used a novel clustering method to identify subtypes of male patients with lower urinary tract symptoms based on detailed multisymptom information.
View Article and Find Full Text PDFPurpose: To improve the potential for finding clinically important subtypes of patients with lower urinary tract symptoms we developed the CASUS (Comprehensive Assessment of Self-reported Urinary Symptoms). We used it to present data on the experiences of lower urinary tract symptoms in treatment seeking women and men from a prospective observational cohort.
Materials And Methods: We created an initial list of lower urinary tract symptoms that were confirmed in 22 qualitative interviews with providers, and 88 qualitative interviews with care seeking and noncare seeking women and men with lower urinary tract symptoms.
Objectives: To describe the relationship between metabolic factors and lower urinary tract symptoms, overactive bladder syndrome (OAB) and urinary incontinence (UI).
Methods: Adult male and female patients who presented to a clinician from the symptoms of lower urinary tract dysfunction research network were recruited. Urinary symptoms (presence of OAB, any UI, stress UI (SUI), urgency UI (UUI), urgency, frequency, and nocturia) were assessed with the lower urinary tract symptoms tool.
The Neuroimaging and Sensory Testing (NIST) Study of the Symptoms of Lower Urinary Tract Dysfunction Research Network (LURN) is a cross-sectional, case-control study designed to investigate whether disrupted brain connectivity and sensory processing are associated with abnormal lower urinary tract symptoms (LUTS) in patients with overactive bladder syndrome (OAB). The NIST Study tests the hypotheses that patients with urinary urgency will demonstrate: (1) abnormal functional and structural connectivity of brain regions involved in urinary sensation on magnetic resonance imaging (MRI), and (2) hypersensitivity to painful (pressure) and non-painful (auditory) sensory stimuli on quantitative sensory testing (QST), compared to controls. Male and female adults (18 years or older) who present at one of the six participating LURN clinical centers for clinical care of their LUTS, with symptoms of urinary urgency with or without urgency urinary incontinence, are eligible to participate.
View Article and Find Full Text PDFPurpose: Women with lower urinary tract symptoms are often diagnosed based on a predefined symptom complex or a predominant symptom. There are many limitations to this paradigm as often patients present with multiple urinary symptoms which do not perfectly fit the preestablished diagnoses. We used cluster analysis to identify novel, symptom based subtypes of women with lower urinary tract symptoms.
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- The study investigated the relationship between mental health, sleep, physical function, and urinary incontinence in women seeking treatment for lower urinary tract symptoms.
- Researchers analyzed data from 510 women, finding that a large majority reported urinary incontinence, with different types noted (stress, urgency, mixed).
- Results indicated that while higher urinary incontinence severity was linked to increased depression and anxiety, it did not significantly affect sleep or physical function among these women.
Article Synopsis
- The study aimed to investigate pelvic floor symptoms in women with lower urinary tract symptoms (LUTS), comparing those with urinary incontinence (UI) to those without.
- Researchers collected data from 510 women at several healthcare centers, using specific questionnaires to assess various pelvic floor issues like bowel symptoms and sexual dysfunction.
- Results showed that women with UI reported more bowel issues and worse sexual function, particularly those with mixed urinary incontinence (MUI) who had the most severe symptoms compared to other types of UI.
Purpose: The primary objective of this study was to evaluate reasons for seeking care among men and women with lower urinary tract symptoms.
Materials And Methods: Participants were recruited from urology and urogynecology clinics, and the community. The sample was enriched with persons expected to have abnormal or diminished bladder sensations (eg participants with lower back surgery and participants 65 years old or older).
Objective: We sought to evaluate the effectiveness and safety of utilizing radiotherapy (RT) with standard fractionation, with or without intraoperative RT (IORT), to treat locally recurrent rectal cancer (LRRC).
Methods: Retrospective review of 25 patients with LRRC treated with standard fractionation RT from 2005 to 2011. 15 patients (60%) had prior pelvic RT and 10 (40%) had synchronous metastases.