Publications by authors named "Jonathan Tiessen"
The spatial organization of cells within a tissue is dictated throughout dynamic developmental processes. We sought to understand whether cells geometrically coordinate with one another throughout development to achieve their organization. The pancreas is a complex cellular organ with a particular spatial organization.
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- Hematopoietic stem cells (HSCs) can regenerate blood cells, but the specific signals that guide them in this process after injury are not well understood.
- During anemia, HSCs take up more iron, which activates genes related to red blood cell production through a mechanism involving the Tet2 protein.
- The study found that HSCs in the spleen increase their numbers and activity in response to anemia, highlighting the critical role of iron in enabling these cells to differentiate into red blood cells.
Histone variants contribute to the complexity of the chromatin landscape and play an integral role in defining DNA domains and regulating gene expression. The histone H3 variant H3.3 is incorporated into genic elements independent of DNA replication by its chaperone HIRA.
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