Synopsis of recent research by authors named "Jonathan Tart"
- Jonathan Tart's research primarily focuses on targeting specific proteins involved in cancer pathways, with an emphasis on developing novel inhibitors for therapeutic applications, including MUS81, HuR, KRAS, and PRC2.
- His recent studies utilize fragment-based drug discovery techniques and innovative assay designs to identify potential small molecule inhibitors that can modulate critical protein functions in cancer, highlighting challenges in targeting low-affinity interactions and addressing complex protein-protein interactions.
- His findings have significant implications for cancer treatment, as they identify promising drug targets and pathways that may lead to more effective therapies, particularly for cancers with dysfunctional DNA-repair mechanisms and other oncogenic processes.
