Publications by authors named "Jonathan T Sy"
Clin Cancer Res
April 2008
Article Synopsis
- Trastuzumab is a monoclonal antibody used to treat breast cancers that overexpress HER2, but its effectiveness may be hindered by its high molecular weight and the tumor microenvironment, affecting its distribution in the body.
- In experiments with mice bearing HER2-positive tumor xenografts, different doses of trastuzumab were administered, and its distribution was analyzed using advanced imaging techniques, highlighting significant variability in how well the drug penetrated tumor tissues.
- The study found that trastuzumab did not uniformly distribute within the tumors, with areas showing little to no drug presence. This incomplete penetration could potentially explain some cases of resistance to trastuzumab treatment.
