Publications by authors named "Jonathan T Minnig"
Article Synopsis
- A series of linear-dendritic poly(ethylene glycol) (PEG) lipids were synthesized using a chemical strategy to investigate their effectiveness in small RNA delivery via lipid-based nanoparticles (DLNPs).
- The study systematically changed the hydrophobic domain by altering lipid alkyl lengths and dendrimer generations, which did not affect nanoparticle size or stability but significantly influenced RNA delivery efficacy.
- First-generation PEG lipids demonstrated effective siRNA delivery, while second- and third-generation PEG lipids failed to do so, highlighting the importance of lipid structure in enhancing RNA delivery capabilities in these nanoparticles.
Intercalation-mediated nucleic acid nanoparticles for siRNA delivery.
Chem Commun (Camb)
October 2016
Tremendous effort has been made to improve stability and delivery efficacy of small RNA therapeutics. However, nearly all current nano-encapsulation carriers utilize the critical balance between only two interacting parameters: RNA-binding electrostatic interactions and nanoparticle-stabilizing hydrophobic interactions. We report the development of intercalation-meditated nucleic acid (IMNA) nanoparticles, which utilize intercalation as a third interaction to enhance small RNA delivery.
View Article and Find Full Text PDFRNA-based cancer therapies are hindered by the lack of delivery vehicles that avoid cancer-induced organ dysfunction, which exacerbates carrier toxicity. We address this issue by reporting modular degradable dendrimers that achieve the required combination of high potency to tumors and low hepatotoxicity to provide a pronounced survival benefit in an aggressive genetic cancer model. More than 1,500 dendrimers were synthesized using sequential, orthogonal reactions where ester degradability was systematically integrated with chemically diversified cores, peripheries, and generations.
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