Real-time voltammetric detection of cocaine-induced dopamine changes in the striatum of freely moving mice.

In the present voltammetric study, we have characterized cocaine-induced changes in evoked dopamine release and uptake in the striatum of freely moving mice in real time. Cocaine induced marked dopamine uptake inhibition measured as apparent K(m) changes, producing a maximal effect 20min following a single injection (15mg/kg, i.p.