Publications by authors named "Jonathan Salazar-Leon"
Obesity is a global health concern implicated in numerous chronic degenerative diseases, including type 2 diabetes, dyslipidemia, and neurodegenerative disorders. It is characterized by chronic low-grade inflammation, gut microbiota dysbiosis, insulin resistance, glucose intolerance, and lipid metabolism disturbances. Here, we investigated the therapeutic potential of environmental enrichment (EE) to prevent the progression of gut dysbiosis in mice with high-fat diet (HFD)-induced metabolic syndrome.
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- Inflammation in adipose tissue due to imbalanced calorie intake and energy expenditure contributes to obesity-related metabolic issues, primarily through cytokines like IL-1β and IL-18.
- A study using caspase-1-deficient mice on different diets showed that IL-18 production is independent of caspase-1, while IL-1β production relies on it.
- These findings clarify cytokine production mechanisms in fat tissue, indicating that IL-18 operates independently of inflammatory signals related to excess calories, while IL-1β production is significantly influenced by caspase-1 activation.
Article Synopsis
- Obesity causes chronic inflammation, leading to insulin and leptin resistance, which can result in diseases like type II diabetes.
- Enhancing the environment (EE) has been found to improve brain functions and reduce inflammation, potentially restoring energy balance in obese individuals.
- In a study with obese mice, an EE was shown to improve glucose metabolism, insulin signaling, and reduce inflammation, suggesting it could be a new treatment for obesity-related metabolic issues.
Aim: The aim of this study was to determine whether a direct relationship existed between absolute telomere length (aTL), obesity and familial functionality in a group of Mexican children.
Methods: We recruited 134 children (52% boys) aged 8-10 years during regular primary care check-ups in 2016 and evaluated physical activity (PA), feeding practices, anthropometrics, body fat percentage (BF%) and family dysfunction. Optimised quantitative PCR determined aTL from genomic deoxyribonucleic acid isolated from saliva samples.
Obesity-induced inflammation, triggered by lipid-mediated activation of the Nlrp3 inflammasome, results in glucose metabolism alterations and type 2 diabetes. This knowledge has been generated using animals deficient for any of the different components of this inflammasome (Caspase-1, Asc or Nlrp3) in the C57BL/6 background. Unlike C57BL/6 mice, which carry allele 2 of the Nlrp1b gene (Nlrp1b2), Balb/c mice that carry allele 1 (Nlrp1b1) are less prone to develop alterations in the glucose metabolism when fed with a high fat diet.
View Article and Find Full Text PDFCervical cancer is the second most common cause of cancer death in women worldwide and the development of new diagnosis, prognostic, and treatment strategies merits special attention. Although surgery and chemoradiotherapy can cure 80%-95% of women with early stage cancer, the recurrent and metastatic disease remains a major cause of cancer death. Many efforts have been made to design new drugs and develop gene therapies to treat cervical cancer.
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