A neonatal in-vitro study on the effect of the inflation pressure on end-tidal carbon dioxide levels.

Background: Describing the association of the peak inflation pressure (PIP) with end-tidal carbon dioxide (ETCO) is a prerequisite for the development of closed loop ventilation in neonatal intensive care. We aimed to develop an in-vitro system to study this relationship.

Methods: A ventilator was connected to a test lung, supplied with a stable CO concentration from a cylinder.