Publications by authors named "Jonathan R Clements"
Article Synopsis
- Animal immunization is the main method for generating antibodies, as it leverages natural processes for producing highly effective antibody clones, but it comes with limitations like being slow and unsuitable for some antigens.
- The AHEAD technology developed uses engineered yeast to mimic the natural process of somatic hypermutation, allowing for rapid and continuous mutation of antibody fragments for better antigen binding.
- This approach led to the development of strong nanobodies targeting the SARS-CoV-2 S glycoprotein and other proteins, providing a fast and efficient framework for creating antibodies.
The predominant approach for antibody generation remains animal immunization, which can yield exceptionally selective and potent antibody clones owing to the powerful evolutionary process of somatic hypermutation. However, animal immunization is inherently slow, has poor compatibility with certain antigens ( . .
View Article and Find Full Text PDF