Publications by authors named "Jonathan P Hosey"

Article Synopsis
  • The objective of the study was to evaluate the evidence regarding the initiation, switching, and discontinuation of disease-modifying therapies (DMTs) for various forms of multiple sclerosis (MS), including clinically isolated syndrome (CIS), relapsing-remitting MS (RRMS), and progressive MS.
  • The analysis included 20 Cochrane reviews and 73 additional research articles, revealing that several DMTs significantly outperformed placebo in reducing relapse rates and disease progression, especially in RRMS and CIS patients.
  • The study highlighted the varying effectiveness and side effects of DMTs and recommended further research on comparative effectiveness, high-efficacy treatment approaches, and the exploration of predictive biomarkers for MS treatment.
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Objective: To develop recommendations for disease-modifying therapy (DMT) for multiple sclerosis (MS).

Methods: A multidisciplinary panel developed DMT recommendations, integrating findings from a systematic review; followed an Institute of Medicine-compliant process to ensure transparency and patient engagement; and developed modified Delphi consensus-based recommendations concerning starting, switching, and stopping DMTs pertinent to people with relapsing-remitting MS, secondary progressive MS, primary progressive MS, and clinically isolated syndromes of demyelination. Recommendations were supported by structured rationales, integrating evidence from one or more sources: systematic review, related evidence (evidence not from the systematic review), principles of care, and inference from evidence.

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This report considers the recommendations of the State Society Task Force (SSTF), which evaluated how the relationship between the American Academy of Neurology (AAN) and neurologic societies of individual states can foster the care of patients with neurologic diseases. The task force also evaluated the role of state neurosociety and state medical society interactions in supporting the profession of neurology. The SSTF recommended that the AAN expand current support services to state neurosocieties and foster additional neurosociety development.

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