Assessment of neurovascular uncoupling: APOE status is a key driver of early metabolic and vascular dysfunction.

Background: Alzheimer's disease (AD) is the most common cause of dementia worldwide, with apolipoprotein Eε4 (APOEε4) being the strongest genetic risk factor. Current clinical diagnostic imaging focuses on amyloid and tau; however, new methods are needed for earlier detection.

Methods: PET imaging was used to assess metabolism-perfusion in both sexes of aging C57BL/6J, and hAPOE mice, and were verified by transcriptomics, and immunopathology.

Assessment of Neurovascular Uncoupling: Status is a Key Driver of Early Metabolic and Vascular Dysfunction.

Background: Alzheimer's disease (AD) is the most common cause of dementia worldwide, with apolipoprotein ε4 () being the strongest genetic risk factor. Current clinical diagnostic imaging focuses on amyloid and tau; however, new methods are needed for earlier detection.

Methods: PET imaging was used to assess metabolism-perfusion in both sexes of aging C57BL/6J, and h mice, and were verified by transcriptomics, and immunopathology.