Publications by authors named "Jonathan Naddaf"
Intracellular zinc protects tumours from T cell-mediated cytotoxicity.
Cell Death Differ
December 2024
Article Synopsis
- Tumours evade immune responses, making cancer immunotherapies less effective, mainly through loss of antigen presentation and cytokine signaling pathways.
- A genome-wide CRISPR/Cas9 screen identified that loss of core-binding factor subunit beta (CBFβ) increases tumour resistance to CAR-T cells, which do not rely on traditional antigen presentation.
- The study found that intracellular zinc levels influence tumour cell susceptibility to T cell killing, suggesting that targeting zinc could enhance the effectiveness of cancer therapies in overcoming immune evasion.