Cutaneous mastocytosis with atypical mast cells and giant cytoplasmic granules.

A 12-year-old male presented with an 8-year history of five firm cream colored papules on the right vertex of the scalp. A biopsy showed a dense infiltrate of monomorphous mast cells involving the dermis and extending into the subcutis. A relatively well-circumscribed cluster of larger cells showed pleomorphic nuclei with bilobed and multilobed morphology.

CD8+ lymphocyte infiltration is an independent favorable prognostic indicator in basal-like breast cancer.

Introduction: Tumor infiltrating lymphocytes may indicate an immune response to cancer development, but their significance remains controversial in breast cancer. We conducted this study to assess CD8+ (cytotoxic T) lymphocyte infiltration in a large cohort of invasive early stage breast cancers, and to evaluate its prognostic effect in different breast cancer intrinsic subtypes.

Methods: Immunohistochemistry for CD8 staining was performed on tissue microarrays from 3992 breast cancer patients.

Prognostic significance of CD8+ T lymphocytes in breast cancer depends upon both oestrogen receptor status and histological grade.

Aims: Results of previous studies on the influence of tumour infiltrating lymphocytes on prognosis of women with breast cancer have been mixed. This study re-evaluates the role of tumour-infiltrating lymphocytes as a prognostic marker in women with breast cancer.

Methods And Results: Immunochemistry staining of CD8(+) T cells was performed on a tissue microarray of 1953 breast carcinomas.

Testicular vasculitis: a series of 19 cases.

Objectives: Because of limited reported cases, it is unknown how often testicular vasculitis represents isolated or systemic disease.

Methods: We report 19 cases (15 consultation; 4 in-house cases) of localized testicular infarction with associated vasculitis spanning 24 years.

Results: All were orchiectomy specimens; detailed clinical information was available in 16 cases.