Publications by authors named "Jonathan L Powell"
Article Synopsis
- Intervention fidelity is crucial in randomized controlled trials as it can impact the effectiveness and outcomes of the intervention being tested, especially for attention control groups where reporting has been inadequate.
- The study aims to enhance fidelity in the attention control arm of a pediatric palliative care trial that evaluates a communication intervention for parents of children with cancer, contrasting it with structured educational discussions on cancer topics.
- Researchers implemented NIH guidelines to design the attention control arm, train care team dyads, and monitor quality to ensure consistency in the conduct of both intervention groups.
Anaplastic lymphoma kinase ( ALK )-fusion sarcomas are rare part of the emerging theoretically targetable tyrosine kinase RAS::MAPK pathway fusion myopericytic-ovoid sarcomas. We report our clinicopathologic and treatment experience with an ALK fusion sarcoma. A novel ELKS/RAB6-interacting/CAST family member 1 - unaligned ALK fusion infiltrative nonmetastatic low-grade sarcoma of the right hand of a 15-month-old male was treated with crizotinib, an ALK tyrosine kinase inhibitor as oral monotherapy, inducing complete radiographic and clinical resolution by 10 months and sustained response now over 12 months after elective discontinuation.
View Article and Find Full Text PDFObjective: To determine whether the varicocele grade is related to the degree of improvement in serum testosterone levels after varicocelectomy.
Materials And Methods: We performed a retrospective review of men with a total serum testosterone level <400 ng/dL who had undergone microsurgical subinguinal varicocelectomy for infertility and/or hypogonadism. All men had clinically palpable left varicoceles and preoperative and postoperative total serum testosterone levels available.