Publications by authors named "Jonathan Komisar"

Background: Anti-N-methyl-D-aspartate (NMDA) receptor encephalitis has been recognised to present with the syndrome of catatonia. In severe cases dysautonomia is representative of malignant catatonia. The treatment with benzodiazepines (BZDs) and electroconvulsive therapy (ECT) may decrease morbidity and mortality in patients presenting with anti-NMDA receptor encephalitis and catatonia.

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Article Synopsis
  • Alcohol is a significant cause of preventable deaths in the U.S., and this study aimed to evaluate the occurrence of phenobarbital-resistant alcohol withdrawal syndrome (AWS) and its risk factors.
  • The study compared two groups of patients who received either a standard or low dose of phenobarbital (PHB) while being treated for AWS, but found no significant difference in the rate of PHB-resistant cases between the two groups.
  • The only notable risk factor found for developing PHB-resistant AWS was the total dose of benzodiazepines taken in the 24 hours prior to receiving PHB.
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A 36-year-old previously healthy woman with no personal or family history of mental illness presented with new-onset psychosis after a diagnosis of symptomatic COVID-19. Her psychotic symptoms initially improved with antipsychotics and benzodiazepines and further improved with resolution of COVID-19 symptoms. This is the first case of COVID-19-associated psychosis in a patient with no personal or family history of a severe mood or psychotic disorder presenting with symptomatic COVID-19, highlighting the need for vigilant monitoring of neuropsychiatric symptoms in these individuals.

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Background: Antenatal diagnosis of congenital heart defects (CHD) can impact outcomes in neonates with severe CHD. Obstetric screening guidelines and the indications for fetal echocardiography (FE) have evolved in an attempt to improve the early prenatal detection of CHD. Analyzing yield for specific indications will help clinicians better stratify at-risk pregnancies.

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