Publications by authors named "Jonathan Kindler"
Article Synopsis
- * Methods: Patients with low-risk and favorable intermediate-risk prostate cancer received a hydrogel spacer and fiducial markers before receiving targeted radiation therapy, with various questionnaires used to assess quality of life before and after treatment.
- * Results: In a small group of 20 patients, treatment showed minor positive and negative impacts on urinary, bowel, sexual, and hormonal functions, with low rates of side effects, while PSA levels decreased on average, indicating a potential treatment benefit.
Background: Dose-escalated radiotherapy is known to improve progression free survival in patients with localized prostate cancer, and recent advances have led to the standardization of ultrahypofractionated stereotactic ablative radiotherapy (SABR) delivered in just 5-fractions. Based on the known effectiveness of the accepted though invasive 2-fraction treatment method of high-dose-rate brachytherapy and given the ubiquity of prostate cancer, a further reduction in the number of treatments of external-beam SABR is possible. This study aims to evaluate the safety, efficacy, and non-inferiority of generalizable 2-fraction SABR compared to the current 5-fraction regimen.
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