Publications by authors named "Jonathan K Shanahan"
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Synopsis of recent research by authors named "Jonathan K Shanahan"
Jonathan K Shanahan's research focuses on the mechanisms of virulence in mycobacterial pathogens, particularly Mycobacterium tuberculosis and Mycobacterium marinum, highlighting the role of specific secretion systems and lipids in promoting host cell damage and immune evasion.
His studies reveal that the ESX-1 secretion system, specifically the substrate ESAT-6, is crucial for damaging phagosomal membranes in macrophages, a key step in the pathogenicity of these bacteria.
Recent findings also indicate that phthiocerol dimycocerosates (PDIMs) synergistically enhance the ability of mycobacteria to permeabilize phagosomes, underscoring the complexity of the interactions between mycobacterial components and host defenses.
