Publications by authors named "Jonathan Jonathan Gwasupika"
Wellcome Open Res
August 2024
Article Synopsis
- African children with severe malaria have high death rates, particularly within the first 24 hours of hospital admission, largely due to lactic acidosis caused by parasite sequestration.
- Sevuparin, a heparin-like drug, may improve outcomes by preventing merozoite invasion and enhancing blood flow in infected individuals when administered early during admission.
- A Phase I trial in Kenya and Zambia will evaluate the safety and optimal dosing of sevuparin in children with severe malaria and lactic acidosis, with results expected to inform future Phase II trials.
