Publications by authors named "Jonathan J L Yap"
Article Synopsis
- The study examines outcomes of three aortic valve replacement (AVR) techniques: transcatheter (TAVI), minimally invasive (MIAVR), and conventional (CAVR), focusing on all-cause mortality rates.
- A total of 27 studies with over 16,000 patients were analyzed, revealing that TAVI initially had lower mortality compared to CAVR, but this advantage diminished after 37.5 months.
- MIAVR demonstrated significantly lower mortality rates than both TAVI and CAVR, although TAVI showed consistent benefits specifically in patients undergoing transfemoral (TF) procedures; however, more research is needed for conclusive results.
Background: Diabetes is associated with poorer outcomes and increased complication rates in STEMI patients undergoing percutaneous coronary intervention (PCI). Data are notably lacking in the Asia-Pacific region. We report the overall association of Diabetes with clinical characteristics and outcomes in STEMI patients undergoing PCI across the Asia-Pacific, with a particular focus on regional differences.
View Article and Find Full Text PDFBackground: Non-alcoholic fatty liver disease (NAFLD) is a well-established risk factor for cardiovascular disease, with ethnic and regional differences noted. With the recent surge of research within this field, we re-examine the evidence associating NAFLD with subclinical atherosclerosis, and investigate potential regional differences.
Methods: This is a systematic review and meta-analysis.
Plasma branched-chain amino acids (BCAA) are consistently elevated in subjects with obesity and type 2 diabetes (T2DM) and correlate with insulin resistance. The association of BCAA with insulin secretion and clearance rates has not been adequately described. To evaluate the relationships between fasting and postprandial plasma BCAA, insulin secretion and insulin clearance.
View Article and Find Full Text PDFBackground QRS duration (QRSd) is a marker of electrical remodeling in heart failure. Anthropometrics and left ventricular size may influence QRSd and, in turn, may influence the association between QRSd and heart failure outcomes. Methods and Results Using the prospective, multicenter, multinational ASIAN-HF (Asian Sudden Cardiac Death in Heart Failure) registry, this study evaluated whether electroanatomic ratios (QRSd indexed for height or left ventricular end-diastole volume) are associated with 1-year mortality in individuals with heart failure with reduced ejection fraction.
View Article and Find Full Text PDFBackground: Asians are predisposed to a lean heart failure (HF) phenotype. Data on the 'obesity paradox', reported in Western populations, are scarce in Asia and have only utilised the traditional classification of body mass index (BMI). We aimed to investigate the association between obesity (defined by BMI and abdominal measures) and HF outcomes in Asia.
View Article and Find Full Text PDFArticle Synopsis
- * Researchers found that individuals could be grouped into clusters based on their daily activities, which reflected different demographic and behavioral traits.
- * While resting heart rates were more closely linked to cardiovascular and metabolic markers, step counts helped reveal important connections between physical activity and heart health, highlighting the role of wearables in improving personalized health and reducing overdiagnosis in active people.