Publications by authors named "Jonathan J Fox"
Article Synopsis
- - The study investigates how aging affects the immune environment in the prostate of mice, aiming to identify when significant changes occur and how these changes relate to disease risk.
- - Researchers found that in young adult mice (3 months old), myeloid cells dominate the immune population, but by 6 to 12 months, there is a notable shift towards T and B lymphocytes.
- - This research highlights the timeline of immune changes in the prostate and suggests that understanding these changes could help develop strategies to mitigate age-related inflammation and associated diseases.
Chronic inflammation in the benign prostate has been associated with a higher risk of developing prostate cancer. While a range of immune lineages is found in the prostate including T cells, B cells and myeloid cells, the specific subsets of immune cells with each major lineage have not been well described. In this study, we use mass cytometry (CyTOF) to comprehensively and reproducibly profile immune cells in mouse and human prostate.
View Article and Find Full Text PDFAging is associated with loss of tissue mass and a decline in adult stem cell function in many tissues. In contrast, aging in the prostate is associated with growth-related diseases including benign prostatic hyperplasia (BPH). Surprisingly, the effects of aging on prostate epithelial cells have not been established.
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