Publications by authors named "Jonathan Ian Silverberg"
Increased loss-of-function filaggrin gene mutation prevalence in atopic dermatitis patients across northern latitudes indicates genetic fitness: A systematic review and meta-analysis.
Exp Dermatol
July 2024
Article Synopsis
- Loss-of-function mutations in the filaggrin gene (FLG) are the strongest genetic risk factor for atopic dermatitis (AD), with a prevalence of 19.1% in AD patients compared to 5.8% in the general population.
- A systematic review and meta-analysis analyzed data from 248 studies to assess the geographic and ethnic distribution of these mutations, finding they are more common in populations living farther north of the Equator.
- Despite a significant association between AD and LoF FLG mutations in the Northern hemisphere, these mutations are less prevalent or absent in some ethnic groups, like Middle Easterners and most Africans, indicating a need for tailored AD management strategies.
Cobalt is a recognized cause of allergic contact dermatitis (ACD); however, detailed information on patient characteristics, sites, and sources is lacking. The aim of the study is to assess trends in patch test reactions to cobalt and associated patient characteristics, common sources, and body sites affected. The study used a retrospective analysis of adult patients who were patch tested to cobalt by the North American Contact Dermatitis Group between 2001 and 2018 (n = 41,730).
View Article and Find Full Text PDFSleep disturbance (SD) is common in atopic dermatitis (AD). We examined the longitudinal course of SD and relationship with itch in AD patients. A prospective, dermatology practice-based study was performed (N = 1295) where patients were assessed at baseline and follow-up visits.
View Article and Find Full Text PDFWe determined which educational and/or psychological interventions were most effective in atopic dermatitis (AD). A systematic review of published studies evaluated the effectiveness of educational and/or psychological interventions in MEDLINE, Embase, SCOPUS, LILACS, Cochrane, China National Knowledge Infrastructure, Taiwan Electronic Periodical Services, and CiNii. Two reviewers conducted title/abstract, full-text review, and data extraction.
View Article and Find Full Text PDFBackground: Sleep disturbance (SD) is common in atopic dermatitis (AD). We examined the longitudinal course of SD and relationship with itch in AD patients.
Methods: A prospective, dermatology practice-based study was performed (N = 1295) where patients were assessed at baseline and follow-up visits.
Background: The relationship between atopic dermatitis (AD) severity, sleep disturbance (SD), and health-related outcomes is not fully elucidated.
Objective: The aim of the study was to determine the prevalence of SD in adult AD and its relationship with AD severity and health outcomes among the US population.
Methods: A cross-sectional, US population-based survey study of 2893 adults was performed.
Background: The impact of childhood atopic dermatitis (AD) on social and behavioral issues is not well understood.
Objective: This study sought to determine the prevalence and predictors of social and behavioral symptoms and functional impairment among US children with AD.
Methods: The 1996 to 2015 Medical Expenditure Panel Surveys were analyzed, including a representative, cross-sectional study of 2553 US children with AD.
Background: Atopic dermatitis (AD) is associated with altered skin barrier, microbiome, and immune dysregulation that may increase risk of skin infections.
Objective: The aim of the study was to determine whether AD is associated with skin infections and related outcomes.
Methods: Data from the 2006 to 2012 National Emergency Department Sample were analyzed, including an approximately 20% sample of all US emergency department (ED) visits (N = 198,102,435 adults or children).
Background: Dust mites (DMs) play a role in type I respiratory allergy. Studies relating to DM irritant versus immune reactions are somewhat conflicting in atopic dermatitis (AD).
Objective: The aim of this study was to assess the diagnostic use of patch testing to DM in patients with AD and other dermatitides.