Publications by authors named "Jonathan I Batchelder"
Article Synopsis
- Infections caused by antibiotic-resistant bacteria, along with persister cells that can survive treatment, are projected to lead to millions of deaths in the future if not addressed.
- This study finds that adding glucose and amino acids to nutrient-deprived bacterial cultures enhances their sensitivity to fluoroquinolones, specifically delafloxacin, a recently approved antibiotic for staph infections.
- The researchers discovered that nutrient stimulation increases the production of harmful reactive oxygen species (ROS), which significantly contributes to the enhanced effectiveness of the antibiotics, despite not directly affecting nucleic acid synthesis.
Antibiotic resistance is a major danger to public health that threatens to claim the lives of millions of people per year within the next few decades. Years of necessary administration and excessive application of antibiotics have selected for strains that are resistant to many of our currently available treatments. Due to the high costs and difficulty of developing new antibiotics, the emergence of resistant bacteria is outpacing the introduction of new drugs to fight them.
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