Publications by authors named "Jonathan Hyak"
Article Synopsis
- Patients with Richter transformation (RT) from chronic lymphocytic leukemia (CLL) generally face a poor prognosis when treated with standard chemotherapy regimens, but venetoclax shows promise as a standalone or combined treatment.
- In a study of 62 RT patients treated with venetoclax alongside various therapies, overall response rates were notable: 36% for BTKi, 54% for R-CHOP, and 52% for other intensive treatments, with varied survival outcomes.
- Certain genetic factors, like del(17p) and TP53 mutations, correlated with lower response rates and shorter survival, while severe side effects were mostly linked to intensive chemoimmunotherapy combined with venetoclax.
Fluorescence in situ hybridization (FISH) to detect the recurrent cytogenetics abnormalities deletion 13q, trisomy 12, deletion 11q, and deletion 17p is important for prognostication in chronic lymphocytic leukemia (CLL). A subset of patients are negative for each of these abnormalities (normal 12/13/11/17 FISH), and outcomes are heterogenous within this group. To elucidate variables important for prognostication in this subgroup we conducted a retrospective analysis of 280 treatment-naïve CLL patients with normal standard CLL FISH results.
View Article and Find Full Text PDFClinical prediction of bacteremia and early antibiotics therapy in patients with solid tumors.
Infect Control Hosp Epidemiol
September 2022
Article Synopsis
- - The study examined how systemic inflammatory response syndrome (SIRS) relates to early antibiotic use and bacteremia in patients with solid tumors at a tertiary-care hospital.
- - Results showed that early antibiotics were given more often to SIRS-positive patients (37%) compared to SIRS-negative ones (22%), but SIRS criteria were not effective at predicting bacteremia, which occurred in 19% of SIRS-positive cases and 13% of SIRS-negative cases.
- - The primary predictors for administering early antibiotics were temperature, tachycardia, and white blood-cell count, but only temperature and tachycardia reliably predicted bacteremia, indicating a need for better models for antibiotic use in these patients.
Objective: To characterize the risks of nonpowder guns commonly used by children for recreation.
Methods: We conducted a retrospective review of children ≤18 years of age treated for nonpowder gun injuries at a pediatric level I trauma center during 2013-2017. Demographics, injury characteristics, treatments, and outcomes were reviewed and analyzed using descriptive statistics.
Purpose: Management of children with adhesive small bowel obstruction (ASBO) is often based on abdominal radiographs (AXR). Our purpose was to determine the significance of paucity of gas on initial AXR.
Methods: Retrospective, single center review of children with ASBO between 2011 and 2015.
Background: Adhesive small bowel obstruction (ASBO) in children is generally managed with initial observation. However, no clear guidelines exist regarding indications to operate. Our purpose was to compare outcomes of ASBO management to determine whether timing of surgery and patient age should affect management.
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