Publications by authors named "Jonathan Haqq"
Scope: Pancreatic cancer remains a disease of poor prognosis, with alternate strategies being sought to improve therapeutic efficacy. Omega-3 fatty acids have shown clinical benefit, and mechanisms of action are under investigation.
Methods And Results: Proliferation assays, flow cytometry, invasion assays, ELISA and western blotting were used to investigate efficacy of omega-3 fatty acids alone and in combination with gemcitabine.
Article Synopsis
- Pancreatic ductal adenocarcinoma (PDAC) is a dangerous type of cancer that is tough to treat because it doesn't respond well to usual therapies and surgery isn’t an option for many patients.
- Researchers are studying the cells around the tumor called pancreatic stellate cells (PSCs) because they seem to help the cancer grow and spread.
- The review discusses many studies that show how PDAC and PSCs work together, suggesting that targeting their relationship could lead to new and better treatments for patients with this cancer.
The use of ex vivo perfused models can mimic the physiological conditions of the liver for short periods, but to maintain normal homeostasis for an extended perfusion period is challenging. We have added the kidney to our previous ex vivo perfused liver experiment model to reproduce a more accurate physiological state for prolonged experiments without using live animals. Five intact livers and kidneys were retrieved post-mortem from sacrificed pigs on different days and perfused for a minimum of 6 hr.
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