Naturally Segregating Variation at Contributes to Nicotine Resistance in .

Identifying the sequence polymorphisms underlying complex trait variation is a key goal of genetics research, since knowing the precise causative molecular events allows insight into the pathways governing trait variation. Genetic analysis of complex traits in model systems regularly starts by constructing QTL maps, but generally fails to identify causative sequence polymorphisms. Previously we mapped a series of QTL contributing to resistance to nicotine in a multiparental mapping resource and here use a battery of functional tests to resolve QTL to the molecular level.